Uncovering mechanosensing mechanisms at the single protein level using magnetic tweezers

Methods : a Companion to Methods in Enzymology
Shimin LeJie Yan

Abstract

Mechanosensing of the micro-environments has been shown to be essential for cell survival, growth, differentiation and migration. The mechanosensing pathways are mediated by a set of mechanosensitive proteins located at focal adhesion and cell-cell adherens junctions as well as in the cytoskeleton network. Here we review the applications of magnetic tweezers on elucidating the molecular mechanisms of the mechanosensing proteins. The scope of this review includes the principles of the magnetic tweezers technology, theoretical analysis of force-dependent stability and interaction of mechanosensing proteins, and recent findings obtained using magnetic tweezers.

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Citations

Sep 1, 2015·Methods : a Companion to Methods in Enzymology·Michael J SiedlikCeleste M Nelson
Feb 21, 2016·Methods : a Companion to Methods in Enzymology·Nicolas BorghiChristophe Lavelle
Aug 3, 2017·Nanotechnology·Xiaodan ZhaoJie Yan
Jul 19, 2019·Molecular Biology of the Cell·Si Ming PangJie Yan
Oct 17, 2019·Biophysics Reviews·Matteo ChighizolaCarsten Schulte
Nov 14, 2020·Current Biology : CB·Tu Anh NguyenGregory Jedd
Dec 21, 2018·Emerging Topics in Life Sciences·Ionel Popa, Ronen Berkovich
May 19, 2021·Cellular Signalling·Yasaswi Gayatri Mishra, Bramanandam Manavathi
Jun 13, 2021·The Journal of Biological Chemistry·Rosemarie E GoughBenjamin T Goult
Aug 13, 2021·The Journal of Physical Chemistry Letters·Miao YuJie Yan
Oct 12, 2017·Chemical Research in Toxicology·Hailey L GahlonDavid Rueda
Nov 21, 2018·ACS Nano·Shimin LeJie Yan

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