PMID: 9188577Jul 1, 1997Paper

Uncovering subdominant cytotoxic T-lymphocyte responses in lymphocytic choriomeningitis virus-infected BALB/c mice

Journal of Virology
R G van der MostA Sette

Abstract

The cytotoxic T-lymphocyte response against lymphocytic choriomeningitis virus (LCMV) in BALB/c mice is predominantly directed against a single, Ld-restricted epitope in the viral nucleoprotein (residues 118 to 126). To investigate whether any Kd/Dd-restricted responses were activated but did not expand during the primary response, we used a BALB/c mutant, BALB/c-H-2dm2, which does not express the Ld molecule. Splenocytes from LCMV-infected BALB/c mice were transferred into irradiated BALB/c-H-2dm2 mice and rechallenged with LCMV. Thus, they were exposed to an antigenic stimulus without the involvement of the immunodominant Ld-restricted epitope. In this adoptive transfer model, the donor splenocytes protected the recipient mice against chronic LCMV infection by mounting a potent Kd- and/or Dd-restricted secondary antiviral response. Analysis of a panel of Kd binding LCMV peptides revealed that residues 283 to 291 from the viral glycoprotein (GP(283-291)) comprise a major new epitope in the adoptive transfer model. Because the donor splenocytes were first activated during the primary infection in BALB/c mice, the GP(283-291) epitope is a subdominant epitope in BALB/c mice that becomes dominant after rechallenge in BALB/c-H-2dm2...Continue Reading

References

Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R J RubockiD R Lee
May 1, 1988·The Journal of Experimental Medicine·R Ahmed, M B Oldstone
Dec 1, 1987·Journal of Virology·R AhmedD D Porter
May 1, 1986·The Journal of Experimental Medicine·D StephanM Steinmetz
Jun 23, 1994·Nature·L L LauR Ahmed
Jan 1, 1995·Immunogenetics·H G RammenseeS Stevanoviíc
Dec 1, 1993·The Journal of Experimental Medicine·M CorrD H Margulies

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Citations

Oct 31, 1998·Immunological Reviews·A GallimoreR Zinkernagel
Jun 8, 1999·Annual Review of Immunology·J W Yewdell, J R Bennink
May 17, 2005·Immunogenetics·Bjoern PetersAlessandro Sette
Nov 16, 2012·Human Vaccines & Immunotherapeutics·Devon J ShedlockDavid B Weiner
Dec 9, 1998·Immunologic Research·J AlexanderA Sette
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sampa SantraNorman L Letvin
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A QuinnE E Sercarz
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christina BartholdyAllan Randrup Thomsen
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erika AssarssonAlessandro Sette
Oct 13, 2011·Expert Review of Vaccines·Julia L Hurwitz
Mar 16, 2007·European Journal of Immunology·Jacqueline M BurrowsScott R Burrows
Jun 18, 2002·Immunology and Cell Biology·Anne S De GrootWilliam Martin
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gary C PienChristine A Biron
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K PechholdD M Harlan
Nov 9, 2005·The Journal of Experimental Medicine·Fleur E TynanScott R Burrows
Jan 1, 2006·Expert Review of Clinical Immunology·Kari Irvine, Jack Bennink
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ian A YorkKenneth L Rock
Mar 7, 2019·Microorganisms·Yiding Yang, Vitaly V Ganusov

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