Uncovering the immune tumor microenvironment in non-small cell lung cancer to understand response rates to checkpoint blockade and radiation.

Translational Lung Cancer Research
Jonathan E SchoenhalsJames W Welsh

Abstract

The study of immunology has led to breakthroughs in treating non-small cell lung cancer (NSCLC). The recent approval of an anti-PD1 checkpoint drug for NSCLC has generated much interest in novel combination therapies that might provide further benefit for patients. However, a better understanding of which combinations may (or may not) work in NSCLC requires understanding the lung immune microenvironment under homeostatic conditions and the changes in that microenvironment in the setting of cancer progression and with radiotherapy. This review provides background information on immune cells found in the lung and the prognostic significance of these cell types in lung cancer. It also addresses current clinical directions for the combination of checkpoint inhibitors with radiation for NSCLC.

Citations

Feb 21, 2018·Journal of Immunotherapy·Daniel V P de AlmeidaAntonio C Buzaid
Jul 10, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Rudolf M HuberAmanda Tufman
Jun 28, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eric C KoSilvia C Formenti
Feb 22, 2021·Seminars in Radiation Oncology·Peter H GoffStephanie K Schaub
Jun 8, 2021·Frontiers in Oncology·Ang LiXuemei Zhang
Jul 9, 2021·Lung Cancer : Targets and Therapy·Nikhil Shukla, Nasser Hanna

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