Uncovering the source of new benzodiazepine prescriptions in community-dwelling older adults'

International Journal of Geriatric Psychiatry
Alex S HalmeCara Tannenbaum

Abstract

Initiatives to reduce benzodiazepine use have been largely unsuccessful despite strong associations with adverse outcomes. Curtailing incident use of benzodizepines is an alternate strategy that has yet to be explored. This study aims to determine the source of incident benzodiazepine prescriptions by comparing the risk of receiving a new prescription upon hospital discharge versus after an ambulatory care clinic visit. Data were derived from 1189 community-dwelling adults aged 65 years naive to benzodiazepine consumption, enrolled in the Étude sur la Santé des Ainés, a prospective 3-year cohort study conducted in Québec, Canada. Health survey questionnaires were linked with provincial administrative databases of prescription and health service claims. Analysis with multivariate Poisson regression models compared the risk of incident benzodiazepine use post-hospitalization versus after an ambulatory care visit. Models were adjusted for sex, age, antidepressant use, and concomitant drugs. Sub-analyses were conducted for chronic prescriptions. Incident benzodiazepine use was 11% over a 2-year period, with 18.3% of prescriptions leading to chronic use (> 90 days). Hospitalization conferred a 2.7-fold greater risk of incident use t...Continue Reading

References

Apr 4, 1992·BMJ : British Medical Journal·D SurendrakumarC J Roberts
Feb 1, 1991·British Journal of Clinical Pharmacology·C EdwardsM D Rawlins
Dec 15, 1989·JAMA : the Journal of the American Medical Association·W A RayW Downey
May 26, 1995·Pharmacy World & Science : PWS·J Dingemanse
Feb 1, 1994·Journal of the American Dietetic Association·R N Varma
Sep 16, 1996·The Medical Journal of Australia·J B HowesL G Howes
Jan 1, 1997·Journal of Psychosomatic Research·H L MillarT M MacDonald
Nov 5, 1998·Lancet·F BarboneT M MacDonald
Feb 13, 1999·Journal of the American Geriatrics Society·R GradD Gayton
Jul 14, 2000·Journal of the American Geriatrics Society·M EganJ Monette
Oct 18, 2000·Pharmacotherapy·S A Blakey, J A Hixson-Wallace
Feb 24, 2001·Journal of the American Geriatrics Society·J T HanlonM Weinberger
Oct 30, 2001·American Journal of Epidemiology·S SchneeweissR J Glynn
Jun 22, 2002·BMJ : British Medical Journal·Seena FazelJohn Danesh
Oct 9, 2002·Journal of the American Geriatrics Society·Kristine E EnsrudUNKNOWN Study of Osteoporotic Fractures Research Group
Dec 24, 2002·Clinical Pharmacology and Therapeutics·Francesco LandiUNKNOWN Silvernet-HC Study Group
Mar 1, 2003·European Journal of Clinical Pharmacology·Rolf van HultenHubert G Leufkens
Oct 7, 2003·International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care·Anita K WagnerDennis Ross-Degnan
Jan 21, 2004·CNS Drugs·Melinda J BarkerSimon F Crowe
Oct 19, 2004·BMC Geriatrics·Carol RancourtJean-Pierre Grégoire
Apr 13, 2005·Archives of Internal Medicine·Josh F PetersonDavid W Bates
Apr 19, 2005·Social Psychiatry and Psychiatric Epidemiology·Matteo BalestrieriFrancesco Donato
May 17, 2005·European Journal of Clinical Pharmacology·Rutger StuffkenAntoine C G Egberts
Sep 17, 2005·Journal of Clinical Pharmacy and Therapeutics·W B DollmanA L Gilbert
Nov 8, 2005·Journal of Psychopharmacology·David S BaldwinUNKNOWN British Association for Psychopharmacology
Nov 15, 2005·BMJ : British Medical Journal·Jennifer GlassUsoa E Busto
Jan 1, 1992·Drug and Alcohol Review·R HeckerG Newbury
Sep 5, 2006·General Hospital Psychiatry·Gregory E Simon, Evette J Ludman
Mar 16, 2007·Journal of General Internal Medicine·Joan M CookJames C Coyne
Apr 25, 2007·Journal of General Internal Medicine·Chaim M BellPaula A Rochon
Jun 8, 2007·European Journal of Clinical Pharmacology·Marie-Laure LarocheLouis Merle
Aug 7, 2007·Archives of Gerontology and Geriatrics·Winit Winit-WatjanaJiraporn Kespichayawattana
Jan 26, 2008·International Journal of Clinical Pharmacology and Therapeutics·P GallagherD O'Mahony
May 8, 2008·British Journal of Clinical Pharmacology·Cornelis S van der HooftBruno H Ch Stricker
Aug 2, 2008·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Prasad S NishtalaTimothy F Chen
Dec 10, 2008·CNS Drugs·Malcolm LaderJohn Donoghue
Jun 2, 2009·Journal of the American Geriatrics Society·Harrison G BloomPhyllis C Zee
Jun 23, 2009·Revue D'épidémiologie Et De Santé Publique·A RogelD Laurier
Oct 29, 2009·Canadian Journal on Aging = La Revue Canadienne Du Vieillissement·Michel PrévilleUNKNOWN Scientific Committee of the ESA Study

❮ Previous
Next ❯

Citations

Oct 21, 2015·Journal of Alzheimer's Disease : JAD·Laura SaarelainenSirpa Hartikainen
Nov 7, 2015·European Psychiatry : the Journal of the Association of European Psychiatrists·T A T KurkoJ Hietala
Nov 28, 2015·British Journal of Clinical Pharmacology·Philipe de Souto BarretoYves Rolland
Feb 24, 2015·The Medical Clinics of North America·Jeffrey Wallace, Douglas S Paauw
Jun 19, 2013·European Psychiatry : the Journal of the Association of European Psychiatrists·C ArbusV Camus
Aug 8, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Justin P TurnerCara Tannenbaum

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.