Uncovering viral protein-protein interactions and their role in arenavirus life cycle

Viruses
Maria Eugenia LoureiroNora Lopez

Abstract

The Arenaviridae family includes widely distributed pathogens that cause severe hemorrhagic fever in humans. Replication and packaging of their single-stranded RNA genome involve RNA recognition by viral proteins and a number of key protein-protein interactions. Viral RNA synthesis is directed by the virus-encoded RNA dependent-RNA polymerase (L protein) and requires viral RNA encapsidation by the Nucleoprotein. In addition to the role that the interaction between L and the Nucleoprotein may have in the replication process, polymerase activity appears to be modulated by the association between L and the small multifunctional Z protein. Z is also a structural component of the virions that plays an essential role in viral morphogenesis. Indeed, interaction of the Z protein with the Nucleoprotein is critical for genome packaging. Furthermore, current evidence suggests that binding between Z and the viral envelope glycoprotein complex is required for virion infectivity, and that Z homo-oligomerization is an essential step for particle assembly and budding. Efforts to understand the molecular basis of arenavirus life cycle have revealed important details on these viral protein-protein interactions that will be reviewed in this article.

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Citations

Jul 23, 2016·Viruses·Luis Martínez-Sobrido, Juan Carlos de la Torre
Feb 1, 2019·Pathogens·María Eugenia LoureiroNora López
Jan 1, 2018·Uirusu·Hideki Tani, Urata Shuzo

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Methods Mentioned

BETA
electron microscopy
myristoylation
pulldown

Related Concepts

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Argentine Hemorrhagic Fever

Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by junín virus (JUNV), a member of the arenaviridae family. Discover the latest research on AHF here.

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