Uncovering viral protein-protein interactions and their role in arenavirus life cycle

Maria Eugenia LoureiroNora Lopez


The Arenaviridae family includes widely distributed pathogens that cause severe hemorrhagic fever in humans. Replication and packaging of their single-stranded RNA genome involve RNA recognition by viral proteins and a number of key protein-protein interactions. Viral RNA synthesis is directed by the virus-encoded RNA dependent-RNA polymerase (L protein) and requires viral RNA encapsidation by the Nucleoprotein. In addition to the role that the interaction between L and the Nucleoprotein may have in the replication process, polymerase activity appears to be modulated by the association between L and the small multifunctional Z protein. Z is also a structural component of the virions that plays an essential role in viral morphogenesis. Indeed, interaction of the Z protein with the Nucleoprotein is critical for genome packaging. Furthermore, current evidence suggests that binding between Z and the viral envelope glycoprotein complex is required for virion infectivity, and that Z homo-oligomerization is an essential step for particle assembly and budding. Efforts to understand the molecular basis of arenavirus life cycle have revealed important details on these viral protein-protein interactions that will be reviewed in this article.


May 1, 1991·Virology·S IapalucciM T Franze-Fernández
May 1, 1994·Virology·S IapalucciM T Franze-Fernández
Feb 2, 2000·Journal of Molecular Biology·K L Borden
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alex KentsisKatherine L B Borden
Sep 13, 2003·Journal of Virology·Rodrigo JácamoMaría T Franze-Fernández
Oct 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mar PerezJuan C de la Torre
Feb 20, 2004·Virology·Simon ViethStephan Günther
Mar 3, 2004·Journal of Virology·Tatjana I CornuJuan Carlos de la Torre
Sep 29, 2004·Journal of Virology·Mar PerezJuan Carlos de la Torre
Nov 27, 2004·Journal of Virology·Meike HassStephan Günther
Dec 4, 2004·Nature Medicine·Thomas W Geisbert, Peter B Jahrling
Dec 21, 2005·Current Opinion in Structural Biology·Cristina Ferrer-OrtaNuria Verdaguer
Dec 21, 2005·Virology·Bettina Hartlieb, Winfried Weissenhorn
Feb 16, 2006·Virology·Ana B Sánchez, Juan C de la Torre
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lukas FlatzDaniel D Pinschewer
Mar 31, 2006·Journal of Virology·Shuzo UrataJiro Yasuda
Sep 29, 2006·Journal of Virology·Meike HassStephan Günther
Nov 7, 2006·Virology Journal·Thomas StreckerWolfgang Garten
Oct 17, 2007·Cellular and Molecular Life Sciences : CMLS·A A V AlbertiniR W H Ruigrok
Jul 8, 2008·Current Opinion in Microbiology·Rémi N CharrelSébastien Emonet

❮ Previous
Next ❯


Jul 23, 2016·Viruses·Luis Martínez-Sobrido, Juan Carlos de la Torre
Feb 1, 2019·Pathogens·María Eugenia LoureiroNora López
Jan 1, 2018·Uirusu·Hideki Tani, Urata Shuzo

❮ Previous
Next ❯

Methods Mentioned

electron microscopy

Related Concepts

Related Feeds

Argentine Hemorrhagic Fever

Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by junín virus (JUNV), a member of the arenaviridae family. Discover the latest research on AHF here.

© 2022 Meta ULC. All rights reserved