Undeclared exposure to St. John's Wort in hospitalized patients

British Journal of Clinical Pharmacology
Meret Martin-FacklamWalter E Haefeli

Abstract

The herbal medicine St. John's Wort (SJW) causes substantial decreases in the plasma concentrations of a range of co-administered drugs. Therefore, we evaluated the extent of systemic exposure to hyperforin and hypericin, two of the main constituents of SJW, in patients on admission and during hospital stay, and compared the results with known use of SJW as documented in the drug chart and detected in additional interviews. One hundred and fifty patients aged > or = 18 years and admitted, between August 2000 and February 2002, to an internal medicine ward of a large German university hospital were included. Hyperforin and hypericin was determined in plasma by a sensitive liquid chromotography/mass spectometry (LC/MS/MS) method. To assess undeclared use of SJW the data were compared to information obtained from drug charts and from up to three interviews that had a particular focus on intake of herbal medicines and self-medication during hospitalization. Hyperforin was detected in 12 patients (plasma concentration on the first day of hospitalization = 12-100 ng ml(-1) in five patients and < 3 ng ml(-1) in seven), and hypericin in five patients (0.5-4.3 ng ml(-1)). Nine patients (6%) were taking/had taken SJW without the knowledg...Continue Reading

References

Sep 1, 1996·Antimicrobial Agents and Chemotherapy·R KerbI Roots
Feb 12, 1998·Anaesthesia·G Hocking, W F deMello
Feb 4, 1998·Biochemical Pharmacology·L L von MoltkeR I Shader
Jun 26, 1999·Lancet·M SchwabK Mörike
Feb 22, 2000·Lancet·F RuschitzkaG Noll
Jun 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·L B MooreS A Kliewer
Sep 9, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A MandelbaumM Wiesel
Feb 13, 2001·International Journal of Pharmaceutics·A R BiliaF F Vincieri
Feb 17, 2001·Clinical Pharmacology and Therapeutics·D DürrK Fattinger
Feb 24, 2001·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M AgrosiD Savio
May 24, 2001·The Journal of Pharmacy and Pharmacology·J BarnesJ D Phillipson
Aug 7, 2001·Journal of the American Pharmaceutical Association : APhA·M WurglicsM Schubert-Zsilavecz
Dec 12, 2001·British Journal of Pharmacology·M D PerloffD J Greenblatt
Dec 26, 2001·Clinical Pharmacology and Therapeutics·K SugimotoA Fujimura
Feb 19, 2002·British Journal of Clinical Pharmacology·Martina HennessyJ Feely
Oct 24, 2002·British Journal of Clinical Pharmacology·L HendersonP Arlett
Jan 22, 2003·British Journal of Clinical Pharmacology·Ute I SchwarzW Kirch
Nov 18, 2003·British Journal of Clinical Pharmacology·Arabelle PfrunderJuergen Drewe
Dec 10, 2003·Clinical Pharmacology and Therapeutics·Stephen D HallJ Christopher Gorski

❮ Previous
Next ❯

Citations

Mar 12, 2009·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·B Grün, W E Haefeli
Feb 23, 2012·European Journal of Clinical Pharmacology·Florentine CarowWalter E Haefeli
Jan 27, 2005·Cancer Chemotherapy and Pharmacology·F PajonkB Fiebich
Sep 22, 2011·Forschende Komplementärmedizin = Research in Complementary Medicine·Matthias Unger
Feb 4, 2010·Der Internist·V HafnerW E Haefeli
Jan 7, 2014·Expert Opinion on Drug Metabolism & Toxicology·Walter Emil Haefeli, Alexandra Carls
May 25, 2005·Paediatric Anaesthesia·Jerrold Lerman
May 26, 2006·British Journal of Clinical Pharmacology·Yuichi MurakamiYasufumi Sawada
Sep 6, 2014·The Journal of Antimicrobial Chemotherapy·Johanna Weiss, Walter Emil Haefeli
Oct 8, 2014·Basic & Clinical Pharmacology & Toxicology·Christoph MarkertWalter Emil Haefeli
Feb 27, 2013·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Syed Ziaur RahmanGerald Münch
Mar 16, 2006·Journal of Clinical Laboratory Analysis·Amitava DasguptaKathy Szelei-Stevens
Jul 30, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Johanna WeissMatthias Unger
Jun 4, 2019·European Journal of Hospital Pharmacy. Science and Practice·Alexander F J SendHanna M Seidling
Jul 10, 2007·Archives of Pathology & Laboratory Medicine·Amitava DasguptaJeffrey K Actor
Apr 6, 2006·Archives of Pathology & Laboratory Medicine·Amitava Dasgupta, David W Bernard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Hepatology
Felix StickelDetlef Schuppan
European Journal of Clinical Pharmacology
Karin RiegerMeret Martin-Facklam
Current Opinion in Oncology
Evan AlleyLynn Schuchter
© 2021 Meta ULC. All rights reserved