Under Development JAK Inhibitors for Dermatologic Diseases

Mediterranean Journal of Rheumatology
Nikolaos SiderisElena Sotiriou

Abstract

Molecular targeting therapies represent a new exciting era in dermatology. A promising novel drug class, subject of intense research, is Janus kinase (JAK) inhibitors. Multiple cytokine receptors signal through the Janus kinase and signal transducer and activator of transcription (STAT) pathway. The pathway plays a central role in innate and adaptive immunity, and haematopoiesis. The understanding of the contribution of JAKs to the immunologic processes of inflammatory diseases led to the development of JAK inhibitors, initially for rheumatologic and hematologic diseases. Soon, their efficacy in some dermatologic conditions was also demonstrated, and today their role as therapeutic agents is thoroughly researched, mainly in atopic dermatitis, psoriasis, vitiligo, and alopecia areata. JAK inhibitors can be administered orally or used topically. As they are relatively new treatment modalities in dermatology, many questions concerning their efficacy and safety remain unanswered. Data from ongoing trials are eagerly awaited. Here, we summarize under development JAK inhibitors for dermatologic diseases.

Citations

Jan 8, 2021·Therapeutics and Clinical Risk Management·Celina DubinEmma Guttman-Yassky
May 28, 2021·Journal of the American Academy of Dermatology·Celina DubinEmma Guttman-Yassky
Aug 28, 2021·Biomedicines·Seok-Young KangHye-One Kim
Aug 28, 2021·The Journal of Allergy and Clinical Immunology·George E FragoulisStefan Siebert

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Clinical Trials Mentioned

NCT03011892
NCT03257644
NCT03745638
NCT03745651
NCT03725722
NCT03826901
NCT03334422

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