Under-expression of CD24 in pre-eclamptic placental tissues determined by quantitative real-time RT-PCR

Fetal Diagnosis and Therapy
Bálint NagyPetronella Hupuczi

Abstract

Pre-eclampsia is a pregnancy-related disorder present in about 5-7% of all pregnancies. CD24 expression was recently reported in different diseases, while it has not yet been determined in pre-eclamptic placental tissues. We collected placental tissues from pre-eclamptic (n = 16) and healthy pregnancies (n = 16). We used the quantitative real-time PCR method with a primer-probe system for determination of CD24 gene expression. We measured CD24 concentrations of 18.94 +/- 26.86 ng/microl in the pre-eclamptic and 53.85 +/- 92.05 ng/microl in the healthy placental tissues (p = 0.03). The quantitative real-time PCR method is suitable to determine CD24 expression in placental tissues. We suppose the low expression of CD24 may cause the enhanced immune reaction and could play a role in the abnormal development of placenta in pre-eclampsia.

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Citations

Feb 21, 2009·Biology of Reproduction·Amanda N Sferruzzi-PerriSarah A Robertson
Nov 5, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yutaka Sadakane, Yasumaru Hatanaka
Feb 11, 2010·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Y Fukuda
Jul 22, 2010·The Tohoku Journal of Experimental Medicine·Shizuko AkiyamaNobuo Yaegashi
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May 12, 2015·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yukio YokoyamaKazuki Kurota
Aug 8, 2021·International Journal of Molecular Sciences·Marei SammarBerthold Huppertz

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