Under-Reported Aspects of Platinum Drug Pharmacology

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Dirk Theile

Abstract

Platinum drugs remain the backbone of many antineoplastic regimens. Among the numerous chemical or pharmacological effects of platinum drugs, some aspects tend to be under-reported. Thus, this perspective paper intends to stress some neglected properties of platinum drugs: first, the physico-chemical characteristics (aquation reaction kinetics) that determine site-specific toxicity; second, the impact on RNA molecules. Knowledge of the 'RNA world' has dramatically changed our understanding of cellular and molecular biology. The inherent RNA-crosslinking properties should make platinum-based drugs interact with coding and non-coding RNAs. Third, we will discuss the impact on the immune system, which is now recognized to substantially contribute to chemotherapy efficacy. Together, platinum drugs are in fact old drugs, but are worth re-focusing on. Many aspects are still mysterious but can pave the way to new drugs or an improved application of the already existing compounds.

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Citations

Jan 13, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Juan OyarzoRamón Messeguer
Mar 30, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Angelamaria CaporaleCarmela Saturnino
Sep 21, 2019·Future Medicinal Chemistry·Ming-Hsien LinJia-You Fang
Sep 4, 2020·British Journal of Clinical Pharmacology·Rémi LonguespéeWalter E Haefeli

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