Under-reporting of serious adverse drug reactions in Sweden

Pharmacoepidemiology and Drug Safety
Martin BäckströmRune Dahlqvist

Abstract

Adverse drug reactions (ADR) constitute a major problem, both from a medical point of view and as an economical burden. Spontaneous reporting of ADRs is one of the methods for post marketing surveillance of drug safety. Under-reporting can also provide an important obstacle to rapid and relevant signal detection. To investigate the rate of under-reporting serious ADRs of selected ICD 10 diagnoses. In order to investigate the under-reporting rate we investigated at five hospitals within the county of Norrbotten in Sweden the total number of diagnosed cases during a period of 5 years (1996-2000) with the following diagnoses: cerebral haemorrhage (I 61.0-I 61.9), pulmonary embolism (I 26.0 and I 26.9), embolism or thrombosis (I 74.0-I 74.9), phlebititis, thrombophlebitits or venous thrombosis (I 80.0-I 80.3, I 80.8 and I 80.9) and portal vein thrombosis and other thrombosis or emboli (I 82.0-I 82.3, I 82.8 and I 82.9). The identity of these patients was obtained through a database search. The patients' case records were then scrutinized by a specially trained nurse and the drugs used at the time of the event were noted. An assessment of the possibility of an ADR was performed using standard WHO causality criteria. Later, database ...Continue Reading

Citations

Mar 31, 2006·European Journal of Clinical Pharmacology·Martin Bäckström, T Mjörndal
Mar 10, 2007·European Journal of Clinical Pharmacology·Susanna M WallerstedtLars Ny
Apr 4, 2007·European Journal of Clinical Pharmacology·Martin BäckströmT Mjörndal
Oct 1, 2008·European Journal of Clinical Pharmacology·Elisabet Ekman, Martin Bäckström
Jan 8, 2009·European Journal of Clinical Pharmacology·Marie-Louise JohanssonSusanna M Wallerstedt
Feb 22, 2012·European Journal of Clinical Pharmacology·Henrik LövborgStaffan Hägg
Jun 19, 2012·European Journal of Clinical Pharmacology·Chiara BiagiDomenico Motola
Aug 24, 2012·European Journal of Clinical Pharmacology·Inês Ribeiro-VazEva Rebelo Gomes
Sep 27, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Peter K KaiserSimon P Kelly
Dec 1, 2007·Journal of Cardiovascular Pharmacology·Luc M HondeghemJohn Camm
Mar 28, 2008·BMC Clinical Pharmacology·Gertrud BrunlöfSusanna M Wallerstedt
Mar 19, 2013·BMC Pharmacology & Toxicology·K C SantoshI Ralph Edwards
Jul 25, 2012·Drug, Healthcare and Patient Safety·Elisabet EkmanMartin Bäckström
Jan 1, 2009·Drug, Healthcare and Patient Safety·C-J TörnhageSusanna M Wallerstedt
Sep 8, 2011·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Neil T Feldman
Aug 11, 2011·American Journal of Pharmaceutical Education·Ramadan Mohamed ElkalmiMuhammad Abdul Hadi
Oct 16, 2009·International Archives of Occupational and Environmental Health·Annet F LenderinkFrank J H van Dijk
Aug 11, 2007·Expert Opinion on Drug Safety·Robbert P van ManenWilliam DuMouchel
Jun 18, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Vincent NicholsJohanne Collin
Oct 22, 2005·Journal of Clinical Pharmacology·Fatemeh FattahiParviz Tabatabaei
Jul 18, 2006·British Journal of Clinical Pharmacology·Stephanie LugardonMaryse Lapeyre-Mestre
Jun 2, 2006·Pharmacoepidemiology and Drug Safety·Karin WesterStaffan Hägg
Jan 26, 2006·British Journal of Clinical Pharmacology·Paul BarrowLesley Wise
Nov 15, 2011·Pharmacoepidemiology and Drug Safety·Maria BygdellJenny M Kindblom
May 15, 2013·Pharmacoepidemiology and Drug Safety·Paul Avillachl'Association des Centres Régionaux de Pharmacovigilance
Oct 21, 2015·Journal of Nursing Management·Joana Isabel O Mendes MarquesMaria T Herdeiro
May 19, 2005·Current Medical Research and Opinion·Stephen Gough
Jun 24, 2015·Enfermería clínica·Ana Zurita-GaraicoecheaCristina Oroviogoicoechea
Jan 26, 2017·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Tim SchutteMichiel A van Agtmael
Mar 30, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Maria T HerdeiroJ J Gestal-Otero
May 13, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Lorna Hazell, Saad A W Shakir
Oct 31, 2006·Pharmacoepidemiology and Drug Safety·Johanna UlfvarsonUlf Bergman
Jan 5, 2008·Pharmacoepidemiology and Drug Safety·Mara McAdamsGerald Dal Pan
Jun 30, 2005·Current Opinion in Allergy and Clinical Immunology·Eva Rebelo Gomes, Pascal Demoly

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