Underactive and overactive bladders are related to motor function and quality of life in Parkinson's disease

International Urology and Nephrology
Zhi LiuTatsuya Yamamoto

Abstract

Overactive bladder occurs in up to 70% and underactive bladder in up to 50% of patients with Parkinson's disease (PD), which is thought to reflect an altered frontal-basal ganglia circuit. However, it is not clear how bladder disorder is related to motor function and to quality of life (QOL) in PD. We studied these relationships by conducting multiple regression (MR) and bivariate correlation (BV) statistical analyses. We recruited 58 PD patients, irrespective of the presence of bladder disorder: 35 men and 23 women of mean age 66.8 years, mean duration of the disease 5.4 years, and median score of Hoehn-Yahr stage 3. We administered a bladder questionnaire including two major types of lower urinary tract symptoms, 'overactive bladder (OAB)' and 'voiding difficulty,' in addition to a QOL index and a pressure-flow urodynamic study to detect detrusor overactivity (DO) during filling; and detrusor weakness, outlet obstruction, and post-void residuals (PVR) during voiding. We analyzed the results using the MR and BV methods. (1) Motor impairment (by HY grades) was significantly related to detrusor weakness (P < 0.05 MR); voiding difficulty, OAB (P < 0.05 BV) (by de novo, levodopa honeymoon, and wearing-off); and voiding difficulty ...Continue Reading

References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Jun 12, 1987·JAMA : the Journal of the American Medical Association·N M Resnick, S V Yalla
Dec 1, 1993·British Journal of Urology·J Malone-Lee, I Wahedna
Mar 23, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·I Araki, S Kuno
Feb 22, 2002·Neurourology and Urodynamics·Paul AbramsUNKNOWN Standardisation Sub-committee of the International Continence Society
Dec 21, 2002·Autonomic Neuroscience : Basic & Clinical·Ryuji SakakibaraTakamichi Hattori
May 2, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Tomoyuki UchiyamaTomonori Yamanishi
Aug 2, 2003·Arquivos de neuro-psiquiatria·Raimundo Nonato Campos-SousaDaniel França Mendes de Carvalho
Sep 15, 2004·Cell and Tissue Research·Jörg B Schulz, Björn H Falkenburger
Aug 4, 2005·International Urogynecology Journal and Pelvic Floor Dysfunction·Charlotte ChalihaStavros Athanasiou
Jan 13, 2006·Neurourology and Urodynamics·Kristian WingeLene Werdelin
Feb 9, 2006·British Journal of Pharmacology·William C de Groat
Mar 15, 2006·Neurourology and Urodynamics·Tatsuya YamamotoTakamichi Hattori
Feb 14, 2009·Neurourology and Urodynamics·Tatsuya YamamotoTakamichi Hattori
Jun 16, 2009·Lancet·Andrew J LeesTamas Revesz
Jan 7, 2010·Age and Ageing·John V Hindle
Feb 10, 2011·Neurourology and Urodynamics·Kuniko TsunoyamaEmina Ogawa
May 3, 2011·Journal of the Neurological Sciences·David S GoldsteinYehonatan Sharabi
Oct 22, 2011·Neurobiology of Disease·Ryuji SakakibaraTatsuya Yamamoto
Apr 5, 2012·Neurourology and Urodynamics·Tatsuya YamamotoSatoshi Kuwabara
Oct 20, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Keiichiro TerayamaTatsuya Yamamoto
Apr 19, 2013·Neurourology and Urodynamics·Shang-Jen ChangStephen Shei-Dei Yang
Dec 18, 2013·Parkinsonism & Related Disorders·Ryuji SakakibaraTsutomu Inaoka
Sep 23, 2014·International Urology and Nephrology·Michael B Chancellor, Ananias Diokno

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Citations

Dec 31, 2015·Current Bladder Dysfunction Reports·Brian T KadowChristopher J Chermansky
Jul 31, 2016·International Urology and Nephrology·Kassem FarajMichael B Chancellor
Apr 21, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M PicilloUNKNOWN PRIAMO Study Group
Feb 27, 2018·Journal of Parkinson's Disease·Yang-Hyun LeeJoong-Seok Kim
Mar 27, 2020·Frontiers in Aging Neuroscience·Zuzanna TkaczynskaInga Liepelt-Scarfone
Jul 26, 2017·Current Bladder Dysfunction Reports·Phillip P Smith
Nov 11, 2017·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Ryuji SakakibaraTomonori Yamanishi
Apr 21, 2020·Journal of Parkinson's Disease·Chunsong JiaTongwen Ou
Dec 19, 2020·Annals of Clinical and Translational Neurology·Joana Afonso RibeiroJalesh N Panicker
Mar 12, 2020·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·E SavardG Amarenco

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