Undercarboxylated osteocalcin concentration in postmenopausal women receiving hormone therapy daily and on alternate days

Menopause : the Journal of the North American Menopause Society
Toshiyuki YasuiMinoru Irahara

Abstract

Undercarboxylated osteocalcin (ucOC) is a sensitive marker of vitamin K status. The authors examined the difference in serum ucOC concentrations in postmenopausal women receiving hormone therapy (HT) daily and on alternate days, and assessed the association between ucOC and triglyceride concentrations, which are related to the transport of vitamin K. Seventy-three postmenopausal women were recruited for this study. Thirty-seven women received 0.625 mg of conjugated equine estrogens (CEE) and 2.5 mg of medroxyprogesterone acetate (MPA) daily, and 36 women received 0.625 mg of CEE and 2.5 mg of MPA on alternate days. The concentrations of serum ucOC, bone turnover markers, lipid profiles, and hormones were measured before and after 12 months of HT. The ucOC concentration in women taking HT daily was significantly (P < 0.01) lower than that in women taking HT on alternate days. Serum ucOC concentrations during HT showed a significant (P < 0.01) inverse correlation with estradiol concentrations during HT. Serum estradiol concentrations during HT showed a significant (P < 0.01) positive correlation with triglyceride concentrations during HT. Furthermore, ucOC concentrations during HT showed a significant (P < 0.05) inverse correlati...Continue Reading

References

Nov 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L PlantalechP D Delmas
Oct 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P SzulcP D Delmas
Oct 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S P RobinsM J Seibel
Apr 1, 1993·The Journal of Clinical Investigation·P SzulcP D Delmas
Mar 1, 1997·The Journal of Clinical Endocrinology and Metabolism·M J SeibelJ P Bilezikian
Mar 1, 1997·The Journal of Clinical Endocrinology and Metabolism·P VergnaudP D Delmas
Jun 13, 1998·The American Journal of Clinical Nutrition·S Lamon-FavaE J Schaefer
Mar 23, 1999·Diagnostic Cytopathology·J A Gray, G K Nguyen
Jan 14, 2000·Journal of Clinical Laboratory Analysis·T YasuiK Hata
Apr 6, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M ShirakiM Miura
Apr 19, 2002·Biochimica Et Biophysica Acta·Leon J Schurgers, Cees Vermeer
May 22, 2002·JAMA : the Journal of the American Medical Association·Robert LindsayJames H Pickar
Jun 4, 2002·The Journal of Nutrition·Nicola M McKeownSarah L Booth
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·Mischa MuirHans-Udo Schweikert
Oct 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Sarah L BoothDouglas P Kiel

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Citations

Jul 14, 2006·Menopause : the Journal of the North American Menopause Society·Toshiyuki YasuiMinoru Irahara
Dec 5, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Sarah L Booth
Apr 21, 2012·Climacteric : the Journal of the International Menopause Society·S LuengratsameerungN Taechakraichana
Jan 30, 2016·Renal Failure·Marek KuźniewskiWładysław Sułowicz
Aug 5, 2010·Archives of Biochemistry and Biophysics·Katherine J MotylAnn V Schwartz
Oct 7, 2011·Cardiovascular Therapeutics·Tim R SullivanMarkus Herrmann
Apr 14, 2009·The International Journal of Artificial Organs·Thilo KruegerVincent Brandenburg

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