Underdevelopment of the Human Hippocampus in Callosal Agenesis: An In Vivo Fetal MRI Study

AJNR. American Journal of Neuroradiology
V KnezovićM Vukšić

Abstract

In subjects with agenesis of the corpus callosum, a variety of structural brain alterations is already present during prenatal life. Quantification of these alterations in fetuses with associated brain or body malformations (corpus callosum agenesis and other related anomalies) and so-called isolated cases may help to optimize the challenging prognostic prenatal assessment of fetuses with corpus callosum agenesis. This fetal MR imaging study aimed to identify differences in the size of the prenatal hippocampus between subjects with isolated corpus callosum agenesis, corpus callosum agenesis and other related anomalies, and healthy controls. Eighty-five in utero fetal brain MR imaging scans, (20-35 gestational weeks) were postprocessed using a high-resolution algorithm. On the basis of multiplanar T2-TSE sequences, 3D isovoxel datasets were generated, and both hippocampi and the intracranial volume were segmented. Hippocampal volumes increased linearly with gestational weeks in all 3 groups. One-way ANOVA demonstrated differences in hippocampal volumes between control and pathologic groups (isolated corpus callosum agenesis: left, P = .02; right, P = .04; corpus callosum agenesis and other related anomalies: P < .001). Differenc...Continue Reading

References

Jan 1, 1968·The Journal of Comparative Neurology·P Rakic, P I Yakovlev
Apr 1, 1996·The Journal of Comparative Neurology·S E Arnold, J Q Trojanowski
Apr 1, 1996·The Journal of Comparative Neurology·S E Arnold, J Q Trojanowski
Jul 3, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·J N GieddF X Castellanos
May 2, 2001·The Journal of Comparative Neurology·B G Rash, L J Richards
Nov 19, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L J Richards
Nov 17, 2005·Nature Reviews. Neuroscience·Giorgio M Innocenti, David J Price
Mar 22, 2007·Nature Reviews. Neuroscience·Lynn K PaulElliott H Sherr
Feb 13, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Fuldem Y DonmezMehmet Coskun
Jan 29, 2011·Pediatric Research·Francois Dominique JacobOrit A Glenn
Feb 22, 2012·Developmental Biology·Divya K UnniLinda J Richards
Oct 6, 2012·Computer Methods and Programs in Biomedicine·François RousseauJean-Louis Dietemann
Apr 18, 2014·Nature Communications·Swathi SrivatsaVictor Tarabykin
Jun 17, 2014·Neuropsychologia·Roger L EricksonWarren S Brown
Sep 20, 2015·Neuropsychologia·Vincent BeauléHugo Théoret
Oct 27, 2015·NeuroImage·Antonios MakropoulosDaniel Rueckert
Apr 20, 2016·Neuropsychologia·Lynn K PaulWarren S Brown

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