PMID: 22555040May 5, 2012Paper

Underexpression of MMP-2 and its regulators, TIMP2, MT1-MMP and IL-8, is associated with prostate cancer

International Braz J Urol : Official Journal of the Brazilian Society of Urology
Sabrina Thalita ReisKatia Ramos Moreira Leite

Abstract

Extracellular matrix homeostasis is strictly maintained by a coordinated balance between the expression of metalloproteinases (MMPs) and their regulators. The purpose of this study was to investigate whether MMP-2 and its specifi c regulators, TIMP-2, MT1-MMP and IL-8, are expressed in a reproducible, specific pattern and if the profiles are related to prognosis and clinical outcome of prostate cancer (PCa). MMP-2, TIMP-2, MT1-MMP and IL-8 expression levels were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) in freshly frozen malignant and benign tissue specimens collected from 79 patients with clinically localized PCa who underwent radical prostatectomies. The control group consisted of 11 patients with benign prostate hyperplasia (BPH). The expression profile of the MMP-2 and its regulators were compared using Gleason scores, pathological stage, pre-operative PSA levels and the fi nal outcome of the PCa. The analysis of 79 specimens of PCa revealed that MMP-2, TIMP-2, MT1-MMP and IL-8 were underexpressed at 60.0%, 72.2%, 62.0% and 65.8%, respectively, in malignant prostatic tissue in relation to BPH samples. Considering the prognostic parameters, we demonstrated that high Gleason score tumors (≥ 7) ove...Continue Reading

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Citations

Jan 10, 2013·International Journal of Technology Assessment in Health Care·Frank HulstaertYves Horsmans
May 8, 2014·Pathology Oncology Research : POR·Daniel Cordeiro GurgelPaulo Roberto Carvalho Almeida
Oct 15, 2013·Developmental Medicine and Child Neurology·Ilona Kopyta, Beata Sarecka-Hujar
Feb 26, 2013·The Journal of Sexual Medicine·Rocco Salvatore Calabrò, Placido Bramanti
Jun 22, 2012·Annals of Human Biology·Peter T EllisonVictoria Wobber
Dec 9, 2014·Expert Review of Medical Devices·Dominic LeePhilippe E Zimmern
Aug 21, 2013·Expert Opinion on Biological Therapy·Anna V van Lingen, J Alfred Witjes
Jan 16, 2013·Expert Opinion on Investigational Drugs·Stavros Gravas, Jean J M C H de la Rosette
Jan 29, 2013·Disability and Rehabilitation·M Peny-DahlstrandG Gosman-Hedstrom
Jan 9, 2016·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Sabrina Thalita dos ReisKatia Ramos Moreira Leite
Jan 1, 2013·Cancer Growth and Metastasis·Sathana DushyanthenGerald M Y Quan
Jul 3, 2020·International Journal of Molecular Sciences·Francisca DiasRui Medeiros
Apr 4, 2021·International Journal of Molecular Sciences·Marley J Binder, Alister C Ward

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