Abstract
Head and neck cancer collectively is one of the most common cancer types in the world. Oral squamous cell carcinoma (OSCC) is the most common subtype of head and neck cancer. SRSF3 is a proto-oncogene and is overexpressed in patients with OSCC. However, the relationship between SRSF3 expression and the clinical outcomes of patients with head and neck cancer remains unclear. By using the cBioPortal for Cancer Genomics, a public online tool originally developed at Memorial Sloan Kettering Cancer Center (New York, NY, USA), it was revealed that patients with head and neck cancer with an underexpression of SRSF3 showed better overall and disease-/progression-free survival rates. Moreover, 227 genes were found to be significantly coexpressed with SRSF3 in head and neck cancer. Then, in combination with the analysis of a previous splice-array dataset that included significantly changed genes after the silencing of SRSF3, four potential target genes of SRSF3 were identified. RBMX and HNRNPL were further confirmed to be target genes of SRSF3. Moreover, the underexpression of RBMX was determined to be significantly associated with a favorable overall survival rate among patients, while patients with an underexpression of both SRSF3 and ...Continue Reading
References
Aug 26, 1998·Molecular and Cellular Biology·H LouS M Berget
Mar 27, 1999·RNA·Y CavalocJ Stévenin
Oct 12, 2002·BMJ : British Medical Journal·R J Sanderson, J A D Ironside
Apr 2, 2003·Molecular Cell·Yingqun HuangJoan A Steitz
Mar 23, 2006·Journal of Cellular Biochemistry·Fernando Martínez-ArribasJosé Schneider
Dec 22, 2006·The EMBO Journal·Kristin M BedardBert L Semler
Oct 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mingxue CuiTom Blumenthal
Mar 14, 2009·The Journal of Biological Chemistry·Bettina HeinrichStefan Stamm
Dec 24, 2010·International Journal of Biological Sciences·Rong JiaZhi-Ming Zheng
Feb 18, 2011·Nucleus·Rasha KanhoushMay Penrad-Mobayed
Feb 22, 2012·Nature Cell Biology·Britt AdamsonStephen J Elledge
Mar 19, 2013·Oncogene·K KurokawaK Rokutan
May 21, 2013·Biochemical and Biophysical Research Communications·Claudia CorboFrancesco Salvatore
Dec 18, 2013·The International Journal of Biochemistry & Cell Biology·Guan-Yu LuWei-Shiang Lin
Sep 7, 2014·Biochimie·Guan-Yu LuWei-Shiang Lin
Sep 23, 2014·RNA·Vladimir MajerciakZhi-Ming Zheng
Nov 19, 2014·Nature Reviews. Clinical Oncology·Hyunseok KangChristine H Chung
Sep 15, 2015·RNA Biology·Hannah GautreyAlison Tyson-Capper
Sep 30, 2015·Scientific Reports·Jihua GuoRong Jia
Dec 26, 2015·Nucleic Acids Research·Masahiko AjiroZhi-Ming Zheng
Jun 10, 2016·Nature Communications·Shihao ShenYi Xing
Jul 20, 2016·International Journal of Medical Sciences·Liu PeiqiJia Rong
Nov 14, 2017·Journal of Proteome Research·Sofía TorresJ Ignacio Casal
Feb 1, 2018·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yukiko ChoTokio Tani
Mar 28, 2018·Proceedings of the National Academy of Sciences of the United States of America·Hao KeBaowei Jiao
Aug 29, 2018·Nature·Mathias MunschauerEric S Lander
Oct 4, 2018·International Journal of Molecular Sciences·Yuki KuranagaYukihiro Akao