Undermining tumor angiogenesis by gene therapy: an emerging field

Current Gene Therapy
S Indraccolo

Abstract

The recent discovery of several molecules that negatively modulate the migration and growth of endothelial cells, collectively referred to as inhibitors of angiogenesis, has made it possible to test the hypothesis that control of angiogenesis might be an effective strategy in controlling tumor growth, as well as ameliorating the course of other life-threatening diseases. Angiogenesis inhibitors are heterogeneous in origin and potency, and their growing list includes products of the proteolysis of larger molecules with a different function, such as angiostatin and endostatin, natural modulators of vascular endothelial growth factor activity, such as sFLT-1, and some cytokines with a marked anti-endothelial activity, such as IL-12 and interferon-alpha. Pre-clinical studies have clearly indicated that most of these factors exert cytostatic rather than cytotoxic effects, thus implying the need for long-term administration in order to obtain a prolonged therapeutic effect. This feature of angiostatic therapy and the difficulty in synthesizing large amounts of recombinant functional proteins have prompted several studies, which have investigated their delivery by a gene therapy approach. This review addresses the several experimental...Continue Reading

Citations

Jul 27, 2007·Clinical & Experimental Metastasis·Adriana AlbiniDouglas M Noonan
Apr 24, 2007·Biochemistry. Biokhimii︠a︡·A V DigtyarS E Severin
May 24, 2005·Journal of Medical Genetics·M AliY J Crow
Jul 20, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher S GondiJasti S Rao
Dec 21, 2006·International Immunopharmacology·K SheejaG Kuttan
Dec 20, 2005·The Journal of Pathology·Lawrence S YoungVivien Mautner
Sep 3, 2005·Cancer Gene Therapy·S E LawlerE A Chiocca
Aug 19, 2007·Journal of Glaucoma·Michael J NolanPaul A Knepper
Jan 28, 2006·Cancer Gene Therapy·R G van der MostD J Nelson

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