Undernutrition during either the pre- or immediate post-weaning period does not affect longevity in Quackenbush mice

Nutritional Neuroscience
G Partadiredja, K S Bedi

Abstract

Diet restriction of rodents during a lengthy period of adult life, can lead to a marked increase in their life-span. However, undernutrition during gestation and/or the suckling period is, paradoxically, known to cause long-lasting 'deleterious' deficits in body and brain structure. It remains uncertain whether or not such undernourished rodents also have an altered life-span. We have now investigated whether a short period of undernutrition of mice either before or immediately after the weaning period could modulate their life-span. Female out-bred Quackenbush mice were undernourished for 40 days by standardised procedures either from conception until weaning or from weaning (day 19) till 60-days-of-age and compared to control mice that had been well-nourished throughout their lives. During the course of their life-span, some mice in each group became seriously ill and, because of ethical considerations, were required to be killed before their 'natural' death. The median age of mice at which they were required to be euthanized due to illness was significantly younger in the well-fed control group compared to the two previously undernourished groups. Of those mice that died of natural causes, it was found that about 90% died be...Continue Reading

References

Jun 15, 1979·International Journal of Cancer. Journal International Du Cancer·M J Tucker
Mar 1, 1976·Mechanisms of Ageing and Development·P E Segall, P S Timiras
Sep 1, 1992·Experimental Gerontology·R Weindruch
Sep 1, 1992·Experimental Gerontology·A Turturro, R Hart
Jan 1, 1990·Proceedings of the Society for Experimental Biology and Medicine·E J Masoro
Nov 1, 1989·Journal of Gerontology·R Weindruch
May 1, 1988·Mechanisms of Ageing and Development·D M Mann
Apr 1, 1988·Mechanisms of Ageing and Development·H OokaP S Timiras
Oct 1, 1986·Mechanisms of Ageing and Development·M L De Marte, H E Enesco
Nov 1, 1986·The Journal of Nutrition·W Nelson, F Halberg
Nov 1, 1985·Journal of Gerontology·H MaedaB P Yu
Jul 13, 1974·Lancet·D S McLaren
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C KuboR A Good
Jan 1, 1982·Gerontology·C L GoodrickN L Cider
Dec 1, 1994·Journal of the American Society of Nephrology : JASN·K TomobeB J Holub
Dec 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J P RichieJ A Zimmerman
Oct 1, 1993·The Journal of Cell Biology·J E Wilhelm, R D Vale
May 1, 1996·Biochemical Society Transactions·C N HalesN J Crowther
Jan 1, 1997·Gerontology·A Aihie Sayer, C Cooper
May 1, 1997·Reviews of Reproduction·D J Barker, P M Clark
Feb 24, 1999·Sports Medicine·G L WarrenR B Armstrong
Feb 21, 1994·Physical Review Letters·K J KingmaD R Veblen
Jun 19, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J Manning, V M Vehaskari
Jan 25, 2003·Experimental Gerontology·Jay A ZimmermanNorman Orentreich
Jan 30, 2004·Nature·Judith ReinhardShaowu Zhang
Jan 30, 2004·Nature·Susan E Ozanne, C Nicholas Hales

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Citations

Jan 5, 2019·Biological Reviews of the Cambridge Philosophical Society·Harrison J F EyckTim S Jessop
Apr 6, 2012·BMC Public Health·Jessica Y Andrews, Stuart A Kinner

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