Underperformed and Underreported Testing for Persistent Oropharyngeal Poliovirus Infections in Primary Immune Deficient Patients-Risk for Reemergence of Polioviruses.

Journal of the Pediatric Infectious Diseases Society
Lester M ShulmanDanit Sofer

Abstract

Individuals with primary immune deficiencies (PIDs) may excrete poliovirus for extended periods and remain a major reservoir for polio after eradication. Poliovirus can spread by fecal-oral or oral-oral transmission. In middle- and high-income countries, oral-oral transmission may be more prevalent than fecal-oral transmission of polioviruses where PIDs patients survive longer. Our aim was to determine the prevalence of prolonged or persistent oropharyngeal poliovirus infections in PIDs. We performed a literature search for reports of prolonged (excreting poliovirus for ≥6 months and ≤5 years) or persistent (excreting poliovirus for >5 years) poliovirus infections in PIDs. There were 140 PID cases with prolonged or persistent poliovirus infections. All had poliovirus-positive stools. Testing of oropharyngeal mucosa was only reported for 6 cases, 4 of which were positive. Molecular analyses demonstrated independent evolution of poliovirus in the gut and oropharyngeal mucosa in 2 cases. Seven PIDs had multiple lineages of the same poliovirus serotype in stools without information about polioviruses in oropharyngeal mucosa. Testing for persistence of poliovirus in oropharyngeal mucosa of PID patients is rare, with virus recovered ...Continue Reading

References

Sep 17, 1998·Journal of Clinical Microbiology·O M KewM A Pallansch
Dec 16, 2003·The Journal of Infectious Diseases·Nino KhetsurianiRoland W Sutter
Sep 13, 2005·Annual Review of Microbiology·Olen M KewMark A Pallansch
May 3, 2006·Biologicals : Journal of the International Association of Biological Standardization·Javier Martín
Dec 23, 2006·Risk Analysis : an Official Publication of the Society for Risk Analysis·Walter DowdleChris Wolff
Dec 23, 2006·Risk Analysis : an Official Publication of the Society for Risk Analysis·Radboud J Duintjer TebbensKimberly M Thompson
Nov 4, 2008·Emerging Infectious Diseases·Ana AvellónGloria Trallero
Dec 19, 2008·The Journal of Infectious Diseases·James P AlexanderUNKNOWN Vaccine-Derived Poliovirus Investigations Group
Jun 25, 2010·The New England Journal of Medicine·Helen E JenkinsNicholas C Grassly
Jul 1, 2010·Emerging Infectious Diseases·Shohreh ShahmahmoodiNima Parvaneh
Jun 17, 2011·The New England Journal of Medicine·Aaron S DeVriesRuth Lynfield
May 23, 2012·Emerging Infectious Diseases·Nicksy GumedeBarry D Schoub
Oct 3, 2013·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·E AnisI Grotto
Oct 16, 2014·The Journal of Infectious Diseases·Cara C BurnsOlen M Kew
Jul 28, 2015·The Lancet Infectious Diseases·Ehud KalinerItamar Grotto
Aug 5, 2016·MMWR. Morbidity and Mortality Weekly Report·Jaume JorbaCara C Burns
Dec 6, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Merav WeilDanit Sofer
Sep 28, 2017·Frontiers in Immunology·Asghar AghamohammadiMark A McKinlay
Oct 26, 2018·MMWR. Morbidity and Mortality Weekly Report·Jaume JorbaCara C Burns
Apr 7, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Merav WeilLester M Shulman

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