Understanding AMD by analogy: systematic review of lipid-related common pathogenic mechanisms in AMD, AD, AS and GN

Lipids in Health and Disease
Qinyuan XuJoanne A Matsubara

Abstract

Age-related macular degeneration (AMD) is one of the leading causes of blindness among the elderly. Due to its complex etiology, current treatments have been insufficient. Previous studies reveal three systems closely involved in AMD pathogenesis: lipid metabolism, oxidation and inflammation. These systems are also involved in Alzheimer's disease, atherosclerosis and glomerulonephritis. Understanding commonalities of these four diseases may provide insight into AMD etiology. To understand AMD pathogenesis by analogy and suggest ideas for future research, this study summarizes main commonalities in disease pathogenesis of AMD, Alzheimer's disease, atherosclerosis and glomerulonephritis. Articles were identified through PubMed, Ovid Medline and Google Scholar. We summarized the common findings and synthesized critical differences. Oxidation, lipid deposition, complement activation, and macrophage recruitment are involved in all four diseases shown by genetic, molecular, animal and human studies. Shared genetic variations further strengthen their connection. Potential areas for future research are suggested throughout the review. The four diseases share many steps of an overall framework of pathogenesis. Various oxidative sources ...Continue Reading

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J RogersP Ward
May 1, 1992·Kidney International·S GuptaD Schlondorff
Jan 1, 1992·Archives of Ophthalmology·H R TaylorN M Bressler
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K FolkersH Tamagawa
Oct 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·C SuarnaR Stocker
Jul 1, 1995·Neurochemistry International·D GiulianJ B Kirkpatrick
Feb 18, 1993·The New England Journal of Medicine·R J JohnsonC E Alpers
Jan 15, 1993·American Journal of Epidemiology·R KleinD L DeMets
Jun 23, 1998·American Journal of Human Genetics·C C KlaverP T de Jong
Aug 4, 1998·The Journal of Experimental Medicine·B M BradtN R Cooper
Mar 18, 1999·The American Journal of Pathology·K YasojimaP L McGeer
Sep 23, 2000·Brain Research. Molecular Brain Research·R StrohmeyerJ Rogers
Jun 19, 2001·Neuroscience Letters·Y ShenJ Rogers
Oct 31, 2001·Neuron·R E Tanzi, L Bertram
Feb 13, 2002·The American Journal of Pathology·Joanne M UpstonRoland Stocker
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tony Wyss-CorayEliezer Masliah
Jul 26, 2002·Journal of the American Society of Nephrology : JASN·John J NearyMichelle P Winn
Feb 5, 2003·Ophthalmic Genetics·Silke SchmidtMichael Gorin
Feb 8, 2003·Brain Research. Molecular Brain Research·Mark P BurnsKaren Duff
Jan 13, 2004·Neurotoxicity Research·A Y SunG Y Sun
Apr 1, 2005·Journal of the American Society of Nephrology : JASN·Gerald B AppelPeter F Zipfel
May 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Gregory S HagemanRando Allikmets
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alberta Y HoiEric F Morand
Oct 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jilin ZhouJanet R Sparrow
Jan 4, 2007·The American Journal of Pathology·Vinay K BhatiaDorian O Haskard
Jul 27, 2007·Investigative Ophthalmology & Visual Science·Cheryl M EthenDeborah A Ferrington
Mar 11, 2008·Investigative Ophthalmology & Visual Science·Martin RudolfChristine A Curcio
Apr 25, 2008·Neurobiology of Aging·Isabelle Le FurJean-Charles Lambert
Jun 21, 2008·Investigative Ophthalmology & Visual Science·Allison NingJoanne Matsubara

❮ Previous
Next ❯

Citations

Jan 30, 2019·Diseases·Paloma Fernández-SanzVega García-Escudero
Jul 16, 2020·Molecular Genetics & Genomic Medicine·Rasa LiutkevicieneVytenis P Deltuva
May 30, 2020·Biomolecules·Jarmo Laihia, Kai Kaarniranta
Dec 29, 2020·Frontiers in Immunology·Seppo Meri, Karita Haapasalo
Feb 22, 2021·Progress in Retinal and Eye Research·Sarah de JongAnneke I den Hollander
Mar 22, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Gopalan GnanaguruPatricia A D'Amore

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
dissections
biopsies

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

Advances in Experimental Medicine and Biology
Robert F MullinsEdwin M Stone
Kathmandu University Medical Journal (KUMJ)
R ThapaS Ruit
© 2022 Meta ULC. All rights reserved