Abstract
Asthma-chronic obstructive pulmonary disease overlap (ACO) differs from asthma and chronic obstructive pulmonary disease (COPD) in demographics, phenotypic characteristics and outcomes, yet the patient experience of ACO is poorly characterized. We aimed to understand and compare the patient experience of symptoms and domains of impact in ACO relative to COPD, and assess the content validity of existing patient-reported outcome (PRO) instruments in ACO. This US qualitative, interview study included patients who met American Thoracic Society/European Respiratory Society spirometric criteria for COPD. Additionally, patients with ACO demonstrated reversibility (forced expiratory volume in 1 s [FEV1] increase ≥ 12% and ≥ 200 mL) to albuterol/salbutamol and an FEV1/forced vital capacity ratio < 0.7. Patients took part in concept elicitation (CE) to explore symptoms and impacts of obstructive lung disease. The Exacerbations of Chronic Pulmonary Disease Tool (EXACT), St George's Respiratory Questionnaire (SGRQ) and a daily wheeze assessment were cognitively debriefed to assess relevance and comprehensiveness. Interviews were analyzed using Atlas.Ti. Concept saturation was evaluated at the symptom level. Twenty patients with ACO and 10 ...Continue Reading
References
Jun 1, 1992·The American Review of Respiratory Disease·P W JonesP Littlejohns
Jun 29, 2004·The European Respiratory Journal·B R CelliUNKNOWN ATS/ERS Task Force
Nov 13, 2007·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Donald L PatrickDianne L Kennedy
May 21, 2009·BMC Pulmonary Medicine·Katayoun BahadoriJ Mark FitzGerald
Oct 7, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Margaret RothmanCharles D Petrie
Jul 28, 2010·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Nancy Kline LeidyUNKNOWN EXACT-PRO Study Group
Sep 4, 2010·American Journal of Respiratory and Critical Care Medicine·Nancy K LeidyUNKNOWN EXACT-PRO Study Group
Feb 18, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Paula KauppiTarja Laitinen
Sep 29, 2011·Respiratory Research·Megan HardinUNKNOWN COPDGene Investigators
Dec 14, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Donald L PatrickLena Ring
Dec 14, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Donald L PatrickLena Ring
Jun 30, 2012·The European Respiratory Journal·Philip H QuanjerUNKNOWN ERS Global Lung Function Initiative
Mar 12, 2013·Expert Review of Clinical Pharmacology·Samuel LouieTimothy E Albertson
May 30, 2013·COPD·Nancy K Leidy, Lindsey T Murray
Mar 7, 2014·Thorax·N K LeidyS Sethi
Oct 8, 2014·Respiratory Research·Nancy K LeidySanjay Sethi
Jan 20, 2017·COPD·Keele E WurstKourtney J Davis
Feb 10, 2017·The European Respiratory Journal·Claus F VogelmeierAlvar Agusti
Apr 22, 2017·Respiratory Medicine·Linda M NelsenPaul W Jones
May 4, 2017·The European Respiratory Journal·Marc Miravitlles
Feb 2, 2018·The European Respiratory Journal