Understanding and treating moyamoya disease in children

Neurosurgical Focus
Jodi L Smith

Abstract

Moyamoya disease, a known cause of pediatric stroke, is an unremitting cerebrovascular occlusive disorder of unknown etiology that can lead to devastating, permanent neurological disability if left untreated. It is characterized by progressive stenosis of the intracranial internal carotid arteries and their distal branches and the nearly simultaneous appearance of basal arterial collateral vessels that vascularize hypoperfused brain distal to the occluded vessels. Moyamoya disease may be idiopathic or may occur in association with other syndromes. Most children with moyamoya disease present with recurrent transient ischemic attacks or strokes. Although there is no definitive medical treatment, numerous direct and indirect revascularization procedures have been used to improve the compromised cerebral circulation, with outcomes varying according to procedure type. Such techniques improve the long-term outcome of patients with both idiopathic and syndrome-associated moyamoya disease. This review provides a comprehensive discussion of moyamoya disease in children, with an emphasis on the most effective surgical treatment options.

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Jul 8, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·David M IbrahimiEdward S Ahn
Dec 31, 2010·Current Neurology and Neuroscience Reports·Jay W Rhee, Suresh N Magge
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Dec 15, 2010·Pediatric Neurology·Philippe Vo VanNathalie Bednarek
Jul 24, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Marc HohenhausVera van Velthoven
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Dec 6, 2012·Dermatologic Therapy·Rigopoulos Dimitris, Daniel Ralph
Jul 5, 2013·The American Journal of Case Reports·Mohamed Nagiub, Iqbal Allarakhia
Mar 12, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Harishchandra Lalgudi SrinivasanJonathan Roth
Apr 8, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Marco PavanelloValeria Capra
Sep 21, 2021·Frontiers in Neurology·Brandon M FoxJohn E Wanebo
Oct 7, 2021·Topics in Magnetic Resonance Imaging : TMRI·Sarah LeeMax Wintermark

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