Understanding aneuploidy in cancer through the lens of system inheritance, fuzzy inheritance and emergence of new genome systems

Molecular Cytogenetics
Christine J YeHenry H Heng

Abstract

In the past 15 years, impressive progress has been made to understand the molecular mechanism behind aneuploidy, largely due to the effort of using various -omics approaches to study model systems (e.g. yeast and mouse models) and patient samples, as well as the new realization that chromosome alteration-mediated genome instability plays the key role in cancer. As the molecular characterization of the causes and effects of aneuploidy progresses, the search for the general mechanism of how aneuploidy contributes to cancer becomes increasingly challenging: since aneuploidy can be linked to diverse molecular pathways (in regards to both cause and effect), the chances of it being cancerous is highly context-dependent, making it more difficult to study than individual molecular mechanisms. When so many genomic and environmental factors can be linked to aneuploidy, and most of them not commonly shared among patients, the practical value of characterizing additional genetic/epigenetic factors contributing to aneuploidy decreases. Based on the fact that cancer typically represents a complex adaptive system, where there is no linear relationship between lower-level agents (such as each individual gene mutation) and emergent properties (...Continue Reading

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Citations

Nov 19, 2019·Frontiers in Genetics·Christine J YeHenry H Heng
Jan 30, 2019·Genes·Kristine SalminaJekaterina Erenpreisa
May 22, 2019·Genes·Ivan Y IourovSergei I Kutsev
May 16, 2019·Genes·Christine J YeHenry H Heng
May 12, 2020·Frontiers in Genetics·Christine J YeHenry H Heng
Nov 16, 2020·Seminars in Cancer Biology·Julie Heng, Henry H Heng
May 7, 2021·Scientific Reports·Andrzej Kasperski, Renata Kasperska
May 16, 2021·Progress in Biophysics and Molecular Biology·Doru Paul
Jun 5, 2021·Medical Hypotheses·Antonio Mazzocca, Stefano Fais
Jul 23, 2021·Genes & Diseases·Arun Upadhyay
May 17, 2021·Progress in Biophysics and Molecular Biology·Julie Heng, Henry H Heng

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Methods Mentioned

BETA
chromosomal aberrations
single-cell sequencing
chromosomal aberration

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