Understanding brain penetrance of anticancer drugs.

Neuro-oncology
Victor A Levin, Benjamin M Ellingson

Abstract

This paper explicates the impact of tumor capillary permeability for glioma World Health Organization (WHO) grades II to IV on brain-penetrant drug entry and distribution within the tumor and the brain adjacent to tumor (leading edge). In addition, we consider the distribution of non-brain penetrant drugs and how, in some cases, large-molecular-weight drugs might achieve good distribution into tumor and brain adjacent to tumor.

References

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Citations

Oct 20, 2020·Frontiers in Oncology·Brij S KarmurAlireza Mansouri
Sep 29, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elizabeth R GerstnerTracy Batchelor
Dec 17, 2020·Biomedicines·Fotios PapadopoulosVasiliki Galani
Apr 23, 2021·Pharmaceutical Development and Technology·Marija GvoicKarmen Stankov

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