Understanding cognitive functioning in glioma patients: The relevance of IDH-mutation status and functional connectivity

Brain and Behavior
Jolanda DerksLinda Douw

Abstract

Cognitive deficits occur frequently in diffuse glioma patients, but are limitedly understood. An important marker for survival in these patients is isocitrate dehydrogenase (IDH) mutation (IDH-mut). Patients with IDH-mut glioma have a better prognosis but more often suffer from epilepsy than patients with IDH-wildtype (IDH-wt) glioma, who are generally older and more often have cognitive deficits. We investigated whether global brain functional connectivity differs between patients with IDH-mut and IDH-wt glioma, and whether this measure reflects variations in cognitive functioning in these subpopulations beyond the associated differences in age and presence of epilepsy. We recorded magnetoencephalography and tested cognitive functioning in 54 diffuse glioma patients (31 IDH-mut, 23 IDH-wt). Global functional connectivity between 78 atlas regions spanning the entire cortex was calculated in two frequency bands (theta and alpha). Group differences in global functional connectivity were tested, as was their association with cognitive functioning, controlling for age, education, and presence of epilepsy. Patients with IDH-wt glioma had lower functional connectivity in the alpha band than patients with IDH-mut glioma (p = 0.040, co...Continue Reading

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Citations

Jan 19, 2020·Journal of Neuro-oncology·Vera BelgersLinda Douw
Apr 14, 2020·PM & R : the Journal of Injury, Function, and Rehabilitation·Julia M ReillySasha E Knowlton
Dec 21, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Elke ButterbrodKarin Gehring
May 6, 2021·Brain Connectivity·Jolanda DerksLinda Douw

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