Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish

Scientific Reports
Konstantin A DeminAllan V Kalueff

Abstract

Stress-related neuropsychiatric disorders are widespread, debilitating and often treatment-resistant illnesses that represent an urgent unmet biomedical problem. Animal models of these disorders are widely used to study stress pathogenesis. A more recent and historically less utilized model organism, the zebrafish (Danio rerio), is a valuable tool in stress neuroscience research. Utilizing the 5-week chronic unpredictable stress (CUS) model, here we examined brain transcriptomic profiles and complex dynamic behavioral stress responses, as well as neurochemical alterations in adult zebrafish and their correction by chronic antidepressant, fluoxetine, treatment. Overall, CUS induced complex neurochemical and behavioral alterations in zebrafish, including stable anxiety-like behaviors and serotonin metabolism deficits. Chronic fluoxetine (0.1 mg/L for 11 days) rescued most of the observed behavioral and neurochemical responses. Finally, whole-genome brain transcriptomic analyses revealed altered expression of various CNS genes (partially rescued by chronic fluoxetine), including inflammation-, ubiquitin- and arrestin-related genes. Collectively, this supports zebrafish as a valuable translational tool to study stress-related patho...Continue Reading

References

May 1, 1991·General and Comparative Endocrinology·E H LimT J Lam
Jan 1, 1988·Physiology & Behavior·E L Rodríguez EchandíaL N Fracchia
Sep 1, 1982·Hormones and Behavior·R M Sapolsky
Jan 1, 1981·Neuroscience and Biobehavioral Reviews·R J Katz
Jun 1, 1982·Pharmacology, Biochemistry, and Behavior·R J Katz
Sep 14, 2000·Genome Research·W B BarbazukS L Johnson
Mar 14, 2001·Journal of Affective Disorders·M RothermundtH Kirchner
Jul 13, 2002·Annals of the New York Academy of Sciences·Ilia J Elenkov, George P Chrousos
Aug 13, 2002·Stress : the International Journal on the Biology of Stress·Andrea Sgoifo, Peter Meerlo
Dec 9, 2003·Stress : the International Journal on the Biology of Stress·C BielajewG Fouriezos
Sep 24, 2004·Archives of Gerontology and Geriatrics·Deniz ErdinçlerEngin Eker
Oct 30, 2004·The American Journal of Psychiatry·Sofia AvissarGabriel Schreiber
Feb 16, 2005·Annual Review of Physiology·Evangelia CharmandariGeorge Chrousos
Apr 23, 2005·Science·Robert J Lefkowitz, Sudha K Shenoy
Jun 9, 2005·BMC Bioinformatics·Seon-Young Kim, David J Volsky
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lu TianPeter J Park
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Feb 8, 2006·Pharmacology & Therapeutics·Vsevolod V Gurevich, Eugenia V Gurevich
Mar 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alicia A Walf, Cheryl A Frye
Oct 6, 2006·Genome Biology·Eugenia V Gurevich, Vsevolod V Gurevich
Oct 7, 2006·Behavioural Brain Research·Yann S MineurWim E Crusio
Apr 5, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Corina O BondiDavid A Morilak
Jun 21, 2007·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·I Kyrou, C Tsigos
Jul 24, 2007·Trends in Pharmacological Sciences·Jonathan D Violin, Robert J Lefkowitz
Aug 21, 2007·Behavioural Brain Research·Noam Miller, Robert Gerlai
Oct 26, 2007·Neurochemical Research·Fiona Thomson, Mark Craighead
Jan 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Cullen L SchmidLaura M Bohn
Jan 19, 2008·Briefings in Bioinformatics·Dougu Nam, Seon-Young Kim
Mar 29, 2008·Annual Review of Clinical Psychology·Elaine WalkerKevin Tessner
Jul 12, 2008·PLoS Computational Biology·Loïc RoyerMichael Schroeder
Oct 17, 2008·Nature·Vaishnav Krishnan, Eric J Nestler
Jan 20, 2009·Biological Psychiatry·Andrew H MillerCharles L Raison
May 5, 2009·Trends in Neurosciences·Carmen Sandi, Gal Richter-Levin
May 29, 2009·BMC Bioinformatics·Weijun LuoPeter J Woolf
Jun 3, 2009·Nature Reviews. Endocrinology·George P Chrousos
Jun 23, 2009·Behavioural Brain Research·Rupert J EganAllan V Kalueff
Dec 10, 2009·The Journal of Pharmacology and Experimental Therapeutics·Moran GolanSofia Avissar

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Methods Mentioned

BETA
RNASeq
ubiquitination
dissection
PCR
RNA-seq

Software Mentioned

DESeq2
PGA
Bioconductor
EBSeq
featureCounts
CytoScape
GAGE
R environment
ARRIVE
Quantus

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