PMID: 11329709May 2, 2001Paper

Understanding enantioselective processes: a laboratory rat model for alpha-hexachlorocyclohexane accumulation

Environmental Science & Technology
E M UlrichR A Hites

Abstract

Since cyclodextrin gas chromatography columns became popular for chiral separations, many researchers have noticed high enantiomeric ratios [ER: (+)-enantiomer/(-)-enantiomer] for alpha-HCH in the brains of wildlife. This investigation used the laboratory rat as a model for these phenomena. Rats were either pretreated with phenobarbital (PB) or left untreated and then dosed with alpha-HCH. Animals were sacrificed after 1 or 24 h. The ER averaged 0.95 +/- 0.01 in blood, 1.29 +/- 0.02 in fat, and 0.77 +/- 0.004 in liver. ERs in brain ranged from 2.8 +/- 0.5 to 13.5 +/- 0.4. Both the tissue concentration distribution and the ERs agree well with those previously reported in wildlife. To determine whether high brain ERs were due to enantioselective metabolism or transport through the blood-brain barrier, alpha-HCH exposed brain and liver tissue slices were compared. Concentrations in the brain slices did not decrease with PB pretreatment but did decrease in the liver slices. Enantiomeric ratios in the brain slices averaged 1.11 +/- 0.02 and were 0.76 +/- 0.03 in liver slices for the PB pretreated rats. These data indicate that the enantioselective metabolism of alpha-HCH by the brain is not the mechanism responsible for high ERs in ...Continue Reading

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Citations

Nov 23, 2006·Chirality·Wentao ZhuZhiqiang Zhou
Nov 3, 2011·Environmental Toxicology and Chemistry·Edward J ScollonGeorge P Cobb
Jun 26, 2014·PloS One·Yiran LiangZhiqiang Zhou
May 23, 2006·Analytical and Bioanalytical Chemistry·Charles S Wong
Aug 9, 2017·Environmental Toxicology and Chemistry·Elin M UlrichWenjian Lao
Apr 13, 2005·Chirality·Qiu Xia WangZhi Qiang Zhou
Apr 16, 2013·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Xianai WuHans-Joachim Lehmler
Jul 22, 2006·Environmental Science & Technology·Nicholas A Warner, Charles S Wong
Apr 12, 2002·Environmental Science & Technology·Charles S WongDerek C G Muir
May 29, 2008·Environmental Science & Technology·Aaron M PeckJohn R Kucklick
Feb 11, 2010·Environmental Science & Technology·Daibin YangLongchuan Yu
Oct 23, 2008·Environmental Science & Technology·Matthew S RossCharles S Wong
Apr 13, 2004·Environmental Science & Technology·Sheryl A LawMichael V Ruby
May 10, 2002·Environmental Science & Technology·Paul F HoekstraDerek C G Muir

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