Understanding Glaucomatous Optic Neuropathy: The Synergy Between Clinical Observation and Investigation

Annual Review of Vision Science
Harry A Quigley

Abstract

Glaucoma is a complex disorder of aging defined by the death of retinal ganglion cells and remodeling of connective tissues at the optic nerve head. Intraocular pressure-induced axonal injury at the optic nerve head leads to apoptosis. Loss of retinal ganglion cells follows a slowly progressive sequence. Clinical features of the disease have suggested and corroborated pathological events. The death of retinal ganglion cells causes secondary loss of neurons in the brain, but only as a by-product of injury to the retinal ganglion cells. Although therapy to lower intraocular pressure is moderately effective, new treatments are being developed to alter the remodeling of ocular connective tissue, to interrupt the injury signal from axon to soma, and to upregulate a variety of survival mechanisms.

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Citations

Jan 13, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Najam A Sharif
Sep 2, 2020·CBE Life Sciences Education·David MenendezKarl S Rosengren
Sep 17, 2020·Annual Review of Vision Science·Philip R WilliamsZhigang He
Nov 18, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Saray TabakElie Beit-Yannai
Dec 16, 2020·Neural Regeneration Research·Pedro NoratXiaorong Liu
Mar 27, 2019·Experimental Neurology·Wolfgang Pita-ThomasValeria Cavalli

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Methods Mentioned

BETA
transmission electron microscopy

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