Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure

The Journal of Pediatrics
Chiara LeoniGiuseppe Zampino

Abstract

Costello syndrome is a rare multisystem disorder caused by mutations in the proto-oncogene HRAS. Failure to thrive is one of its cardinal clinical features. This study documents that individuals with Costello syndrome have increased resting energy expenditure. We speculate this could be one of the potential mechanisms causing failure to thrive.

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Citations

Oct 6, 2016·European Journal of Medical Genetics·Annie T G ChiuBrian H Y Chung
Jun 21, 2018·Endocrine Reviews·Mylène TajanArmelle Yart
Jun 22, 2019·American Journal of Medical Genetics. Part a·Karen W GrippKatherine A Rauen
Aug 9, 2019·Cytogenetic and Genome Research·Naye ChoiChang Won Choi
Nov 10, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Armelle Yart, Thomas Edouard
Jul 11, 2020·American Journal of Medical Genetics. Part a·Barbara ParmaAngelo Selicorni
Aug 28, 2020·American Journal of Medical Genetics. Part a·Chiara LeoniGiuseppe Zampino
Jun 20, 2019·Frontiers in Molecular Neuroscience·Liang QuYuan Wang
Jun 24, 2020·Journal of Medical Genetics·Roope A KallionpääJuha Peltonen
Feb 8, 2020·Molecular Aspects of Medicine·L DardR Rossignol

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