Understanding how data triangulation identifies acute toxicity of novel psychoactive drugs.

Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology
D M Wood, P I Dargan

Abstract

Over the last decade, there has been an increase in the availability and use of novel psychoactive substances (also known as "legal highs"). There is limited information available on the potential acute toxicity (harms) associated with the use of these novel psychoactive substances. Gold standard evidence, such as animal studies or human clinical trials, is rarely available to users or healthcare professionals. However, it is possible to use triangulation of data on the acute toxicity from multiple sources to describe the overall pattern of toxicity associated with a novel psychoactive substance. In this review, we will describe these potential data sources, which include self-reported toxicity on internet discussion fora, data from sub-population user surveys, data from regional and national poisons information services and published case reports and case series. We will then describe how pattern of acute toxicity associated with the use of the cathinone mephedrone (4-methylmethcathinone) was established using triangulation of these different data sources.

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Citations

Jul 17, 2012·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·D M Wood, P I Dargan
Sep 10, 2014·Harm Reduction Journal·Christophe Soussan, Anette Kjellgren
Aug 8, 2014·Clinical Medicine : Journal of the Royal College of Physicians of London·Christopher D Smith, Stefanie Robert
Apr 8, 2014·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Hwee Min D LeePaul I Dargan
Jun 5, 2013·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Wui Ling ChanPaul I Dargan
Nov 29, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Sindhu SiddiqiDavid M Wood
Nov 2, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Fridtjof HeyerdahlPaul I Dargan
Oct 28, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Alison M DinesUNKNOWN Euro-DEN Research Group
Mar 25, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·D M WoodP I Dargan
Nov 5, 2015·Drug and Alcohol Dependence·Johanna J Nugteren-van LonkhuyzenLaura Hondebrink
May 18, 2016·The International Journal on Drug Policy·Christophe Soussan, Anette Kjellgren
Aug 30, 2014·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Hisham NizarDavid M Wood
Mar 20, 2015·Substance Abuse : Research and Treatment·Christophe Soussan, Anette Kjellgren
Sep 10, 2015·British Journal of Hospital Medicine·Kathleen S BonniciDavid M Wood
Jan 24, 2020·Journal of Psychopharmacology·Souleiman El BalkhiFranck Saint-Marcoux
Sep 17, 2020·Nordisk alkohol- & narkotikatidskrift : NAT·Christophe Soussan, Anette Kjellgren

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