Understanding how microbiomes influence the systems they inhabit

Nature Microbiology
Ed K HallMatthew D Wallenstein

Abstract

Translating the ever-increasing wealth of information on microbiomes (environment, host or built environment) to advance our understanding of system-level processes is proving to be an exceptional research challenge. One reason for this challenge is that relationships between characteristics of microbiomes and the system-level processes that they influence are often evaluated in the absence of a robust conceptual framework and reported without elucidating the underlying causal mechanisms. The reliance on correlative approaches limits the potential to expand the inference of a single relationship to additional systems and advance the field. We propose that research focused on how microbiomes influence the systems they inhabit should work within a common framework and target known microbial processes that contribute to the system-level processes of interest. Here, we identify three distinct categories of microbiome characteristics (microbial processes, microbial community properties and microbial membership) and propose a framework to empirically link each of these categories to each other and the broader system-level processes that they affect. We posit that it is particularly important to distinguish microbial community propert...Continue Reading

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Citations

May 28, 2019·Environmental Microbiology·Marie SimoninEmily S Bernhardt
May 31, 2020·FEMS Microbiology Ecology·Michael E Van NulandKabir G Peay
Mar 12, 2019·Frontiers in Microbiology·Shweta JaiswalPratyoosh Shukla
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Feb 1, 2022·Bioengineered·Weichen RanJiaqi Zhang

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Methods Mentioned

BETA
PCR
flow cytometry

Software Mentioned

NanoSims

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