Understanding how morphogens work

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
J C SmithP H Williams

Abstract

In this article, we describe the mechanisms by which morphogens in the Xenopus embryo exert their long-range effects. Our results are consistent with the idea that signalling molecules such as activin and the nodal-related proteins traverse responding tissue not by transcytosis or by cytonemes but by movement through the extracellular space. We suggest, however, that additional experiments, involving real-time imaging of morphogens, are required for a real understanding of what influences signalling range and the shape of a morphogen gradient.

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Citations

Oct 2, 2009·Nature Cell Biology·Ive De SmetTom Beeckman
Jan 15, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael Whitaker, Jim Smith
Nov 4, 2010·Journal of Theoretical Biology·Lewis Wolpert
Jan 26, 2011·Macromolecular Bioscience·Eric H NguyenWilliam L Murphy
Dec 13, 2018·Frontiers in Physiology·Laura J A Hardwick, Anna Philpott
Nov 27, 2020·Frontiers in Cell and Developmental Biology·Andrew B Goryachev, Moisés Mallo
Feb 12, 2015·Development·Siim Pauklin, Ludovic Vallier

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