Understanding How the Subcommissural Organ and Other Periventricular Secretory Structures Contribute via the Cerebrospinal Fluid to Neurogenesis

Frontiers in Cellular Neuroscience
Maria M GuerraEsteban M Rodríguez

Abstract

The dynamic and molecular composition of the cerebrospinal fluid (CSF) and, consequently, the CSF physiology is much more complex and fascinating than the simplistic view held for decades. Signal molecules either transported from blood to CSF or secreted into the CSF by circumventricular organs and CSF-contacting neurons, use the CSF to reach their targets in the brain, including the pre- and postnatal neurogenic niche. The subcommissural organ (SCO), a highly conserved brain gland present throughout the vertebrate phylum, is one of the sources for signals, as well as the choroid plexus, tanycytes and CSF-contacting neurons. The SCO secretes into the fetal and adult CSF SCO-spondin, transthyretin, and basic fibroblast growth factor. These proteins participate in certain aspects of neurogenesis, such as cell cycle of neural stem cells, neuronal differentiation, and axon pathfinding. Through the CSF, the SCO-secretory proteins may reach virtually any target in the embryonic and adult central nervous system. Since the SCO continues to secrete throughout life span, it seems likely that the neurogenetic property of the SCO compounds would be targeted to the niches where neurogenesis continues in adulthood. This review is aimed to br...Continue Reading

References

Dec 1, 1976·The Journal of Endocrinology·E M Rodríguez
Jan 1, 1992·International Review of Cytology·E M RodríguezC R Yulis
Feb 29, 1988·Neuroscience Letters·P GhianiM A Masini
Jan 1, 1969·Zeitschrift für Zellforschung und mikroskopische Anatomie·E M Rodríguez
Sep 30, 1966·Annals of the New York Academy of Sciences·W C Worthington, R S Cathcart
Jan 1, 1984·Cell and Tissue Research·E M RodríguezR Yulis
Oct 24, 1994·Neuroscience Letters·C D BalabanW B Severs
May 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A K Johnson, P M Gross
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·A Guadaño-FerrazJ Bernal
Apr 24, 1999·Trends in Neurosciences·C Nicholson
Jun 20, 2001·Developmental Biology·N BillonM Raff
Oct 9, 2001·Brain Research. Molecular Brain Research·H G RichterE M Rodríguez
Nov 1, 2001·Annual Review of Cell and Developmental Biology·J C Adams
Apr 9, 2002·Journal of Endocrinological Investigation·J Bernal
Jul 24, 2002·Brain : a Journal of Neurology·Farhad MashayekhiJaleel A Miyan
Sep 5, 2002·The Journal of Comparative Neurology·Frederic MercierGlenn I Hatton
Feb 20, 2003·Brain Research. Molecular Brain Research·Teresa CaprileEsteban Rodríguez
May 29, 2003·Canadian Journal of Physiology and Pharmacology·Jaleel A MiyanMahjuib Zendah
Jan 1, 1958·Zeitschrift für Zellforschung und mikroskopische Anatomie·J R SOTELO, O TRUJILLO-CENOZ
Mar 24, 2004·Cell·Elaine FuchsGeraldine Guasch
Apr 20, 2004·The International Journal of Biochemistry & Cell Biology·Richard P Tucker
Jun 16, 2004·Cell and Tissue Research·Mercedes ToméJose Manuel Pérez-Fígares
Oct 8, 2004·Brain Research. Molecular Brain Research·Hans G RichterEsteban M Rodríguez
Feb 25, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G F LemkineB A Demeneix
Mar 25, 2005·Physiological Reviews·Djoher Nora AbrousMichel Le Moal
Apr 23, 2005·Cell and Tissue Research·H A MontecinosE M Rodríguez
Jun 15, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Lia Scotti Campos
Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Ronald M Lechan, Csaba Fekete
Nov 16, 2005·Proteomics·Carolina ParadaDavid Bueno

❮ Previous
Next ❯

Citations

Dec 14, 2005·International Review of Cytology·Esteban M RodríguezPedro Amat
Jan 31, 2019·Journal of Neuroendocrinology·Esteban RodríguezJuan Luis Blázquez
Jan 20, 2018·Endocrine Reviews·Vincent PrevotJerome Clasadonte
Aug 7, 2017·Cellular and Molecular Life Sciences : CMLS·Vladimir Korzh
Mar 3, 2017·Neural Regeneration Research·Elham HashemiRamin Pouriran
Jan 12, 2020·Nature Communications·Susanne LaukoterSimon Hippenmeyer
Feb 23, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ryann M FameHazel L Sive
Dec 28, 2017·Journal of Anatomy·Clemens Kiecker
Nov 11, 2019·Seminars in Cell & Developmental Biology·Vladimir Korzh, Igor Kondrychyn
Jul 13, 2021·Frontiers in Neuroanatomy·Francisco Aboitiz, Juan F Montiel
Aug 10, 2021·Frontiers in Cell and Developmental Biology·Laura Maeso-AlonsoMaria C Marin
Oct 4, 2021·Fluids and Barriers of the CNS·Vania SepúlvedaTeresa Caprile

❮ Previous
Next ❯

Methods Mentioned

BETA
Scanning electron microscopy
Electron microscopy
Phase contrast microscopy

Related Concepts

Related Feeds

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.