Understanding involvement in surgical orthopaedic randomized controlled trials: A qualitative study of patient and health professional views and experiences

International Journal of Orthopaedic and Trauma Nursing
Jeremy HorwoodRachael Gooberman-Hill

Abstract

Factors influencing patients' motivations for enrolling in, and their experiences of, orthopaedic randomized controlled trials (RCTs) are not fully understood. Less is known about healthcare professionals' (HCP) experiences of RCT involvement. This study investigates patients' and HCPs' views and experiences of RCT participation and delivery to inform the planning of future RCTs. Total hip or knee replacement patients (n = 24) participating in the single-center double-blind APEX RCTs of an intra-operative anesthetic intervention and HCPs (n = 15) involved in trial delivery were interviewed. Data were audio-recorded, transcribed, anonymized and thematically analyzed. Although altruistic reasons for RCT participation were common, patients also weighed up demands of the RCT with the potential benefits of taking part, demonstrating the complex and conditional nature of trial participation. HCPs were interested in RCT involvement as a means of contributing towards advances in medical knowledge and also considered the costs and benefits of RCT involvement. Patients and HCPs value involvement in RCTs that they see as relevant and of value, while imposing minimum burden. These findings have important implications for the design of meth...Continue Reading

References

Apr 1, 1995·Research in Nursing & Health·M Sandelowski
Jun 6, 2003·European Journal of Cancer Care·K Cox, J McGarry
Aug 9, 2005·Social Science & Medicine·Norma Morris, Brian Bàlmer
Sep 26, 2006·The American Journal of Bioethics : AJOB·Steven Joffe
Nov 15, 2007·Health Technology Assessment : HTA·M K CampbellUNKNOWN STEPS group
Jul 16, 2008·Journal of Clinical Epidemiology·Jenny L DonovanUNKNOWN ProtecT Study Group
Jul 29, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ajay D WasanWalter M Robinson
Apr 1, 2008·Indian Journal of Orthopaedics·Harman ChaudhryMohit Bhandari
Dec 18, 2010·Clinical Trials : Journal of the Society for Clinical Trials·Louise Locock, Lorraine Smith
Mar 6, 2012·Clinical Trials : Journal of the Society for Clinical Trials·Ricki CarrollScott D Halpern
Aug 1, 2012·The Journal of Bone and Joint Surgery. American Volume·Marc F Swiontkowski, Julie Agel
Aug 1, 2012·The Journal of Bone and Joint Surgery. American Volume·Paul TornettaMohit Bhandari
Apr 5, 2013·Journal of Clinical Nursing·Ralph TrammVerena Schadewaldt
May 11, 2013·Qualitative Health Research·Yandisa Sikweyiya, Rachel Jewkes
Dec 21, 2013·Musculoskeletal Care·Emma C JohnsonRachael Gooberman-Hill

❮ Previous
Next ❯

Citations

Jul 21, 2016·Philosophy, Ethics, and Humanities in Medicine : PEHM·Whitney BarnettDan J Stein
Sep 29, 2018·Health Technology Assessment : HTA·Freddie C HamdyTom A Leslie
Jun 4, 2019·Journal of Alzheimer's Disease : JAD·Clare ClementJeremy Horwood
Oct 13, 2019·BMJ Open·Nathan N O'HaraUNKNOWN PREVENT CLOT Stakeholder Committee
Aug 11, 2019·Trials·Emma Elizabeth PhelpsUNKNOWN TrAFFix study co-applicants
Oct 8, 2020·The Cochrane Database of Systematic Reviews·Catherine HoughtonLinda M Biesty

❮ Previous
Next ❯

Clinical Trials Mentioned

ISRCTN96095682

Software Mentioned

APEX

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.