Understanding myocardial infarction

F1000Research
Moussa Saleh, John A Ambrose

Abstract

Over the last 40 years, our understanding of the pathogenesis of myocardial infarction has evolved and allowed new treatment strategies that have greatly improved survival. Over the years, there has been a radical shift in therapy from passive healing of the infarction through weeks of bed rest to early discharge usually within 2 to 3 days as a result of immediate reperfusion strategies and other guideline-directed medical therapies. Nevertheless, challenges remain. Patients who develop cardiogenic shock still face a high 30-day mortality of at least 40%. Perhaps even more important is how do we identify and prevent patients from developing myocardial infarction in the first place? This article discusses these milestones of therapy and considers important issues for progress in the future.

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Citations

Mar 17, 2020·Frontiers in Bioengineering and Biotechnology·Assaf Bar, Smadar Cohen
Jul 19, 2020·Cardiovascular Drugs and Therapy·Pappitha RajaDerek P Brazil
Jul 23, 2020·Frontiers in Bioengineering and Biotechnology·Israel Gonzalez de TorreJose-Carlos Rodriguez-Cabello
Nov 28, 2020·Archives of Pharmacal Research·Pusoon Chun
Jan 1, 2021·Journal of the American Heart Association·Stacey E AlexeeffStephen Sidney
Jan 28, 2021·International Journal of Molecular Sciences·Ju Hun SuhJung Min Lee
Feb 21, 2021·International Journal of Biological Macromolecules·Jéssica WoukAneli M Barbosa-Dekker
May 1, 2021·International Journal of Molecular Sciences·Michal Kowara, Agnieszka Cudnoch-Jedrzejewska
Jun 21, 2021·The Veterinary Journal·Celine Brugada-TerradellasPascale Smets
Dec 10, 2020·Current Protein & Peptide Science·Ishita SharmaSandeep Arora

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Methods Mentioned

BETA
coronary artery bypass

Related Concepts

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Cardiogenic Shock

Cardiogenic shock is a devastating consequence of acute myocardial infarction and is associated with an extremely high mortality. Here is the latest research.

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