Understanding netrins and semaphorins in mature endothelial cell biology

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Huayu ZhangJanine M van Gils

Abstract

Netrins and semaphorins are known as neuronal guidance molecules that are important to the facilitate patterning of the nervous system in embryonic development. In recent years, their function has been broadened to guide development in other systems, including the vascular system, where netrins and semaphorins critically contribute to the development of the vascular system. Evidence is accumulating that these guidance cues are also of critical importance in the biology of the mature endothelium by regulating the maintenance of endothelial quiescence. Here we review our current insights into the roles of netrins and semaphorins in endothelial cell survival, self-renewing, barrier function, response to wall shear stress, and control of the vascular tone. We also provide suggestions for future research into the functions of netrins and semaphorins in mature endothelial cell biology.

Citations

Mar 30, 2019·Journal of Nucleic Acids·Caroline Suzanne BruikmanJanine Maria van Gils
Feb 27, 2020·International Journal of Molecular Sciences·Huayu ZhangJanine M van Gils
Apr 28, 2020·Journal of Leukocyte Biology·Dianne VreekenJanine Maria van Gils
Jan 30, 2021·Basic Research in Cardiology·Marius KellerPeter Rosenberger
Feb 27, 2021·The International Journal of Biochemistry & Cell Biology·Huayu ZhangJanine M van Gils
Mar 11, 2021·Cellular and Molecular Life Sciences : CMLS·Timothy J A Chico, Elisabeth C Kugler
May 22, 2021·Frontiers in Cardiovascular Medicine·Dianne VreekenJanine Maria van Gils
Aug 24, 2021·Cells & Development·Marie OuarnéCláudio Areias Franco

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