Understanding pluripotency--how embryonic stem cells keep their options open

Molecular Human Reproduction
B V JohnsonR A Keough

Abstract

Embryonic stem (ES) cells have the capacity to proliferate indefinitely in culture while maintaining the ability to differentiate to form any of the cells of the body. This unique combination of functions suggests that these cells could provide a potentially unlimited source of differentiated cells for the treatment of disease and aging. Understanding the molecular processes that underpin these functions in ES cells will allow us to harness their potential and develop strategies that control their differentiation. Combination of controlled differentiation with ground-breaking technologies for the reversal of somatic cells to an ES cell-like state promise the generation of patient-derived pluripotent cell lines for the treatment of disease in the future.

References

Aug 15, 1996·Genes & Development·B Panning, R Jaenisch
Dec 28, 1999·Reproduction, Fertility, and Development·T A PeltonP D Rathjen
Feb 2, 2002·Science·Jose B CibelliMichael D West
Sep 14, 2002·Science·Miguel Ramalho-SantosDouglas A Melton
Sep 14, 2002·Science·Natalia B IvanovaIhor R Lemischka
Nov 12, 2002·Nature Biotechnology·Ren-He XuJames A Thomson
Jan 7, 2003·Genes & Development·Ariel A AvilionRobin Lovell-Badge
Apr 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Xiaoxia QiGuang-Quan Zhao
Jul 28, 2004·Stem Cells·Rohan K HumphreyAlberto Hayek
Nov 13, 2004·Cell Cycle·Francis BurrowsAdeela Kamal
Nov 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ichiro HirataniDavid M Gilbert
Jan 28, 2005·Development·Peter CartwrightStephen Dalton
Feb 22, 2005·Journal of Cellular Biochemistry·Margaret M Panning, David M Gilbert
Mar 4, 2005·Molecular and Cellular Biology·Takao KurodaTakashi Tada
Apr 26, 2005·Stem Cells·Sun Kyung OhShin Yong Moon
Sep 1, 2005·Bioscience Reports·J B Gurdon, J A Byrne
Sep 13, 2005·Cell·Laurie A BoyerRichard A Young
Sep 15, 2005·Human Molecular Genetics·Tariq EnverPeter W Andrews
Sep 24, 2005·Journal of Cell Science·Ludovic VallierRoger A Pedersen
Jan 10, 2006·Developmental Cell·Eran MeshorerTom Misteli
Jan 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tobias BrambrinkRudolf Jaenisch
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Atsushi SuzukiJuan Carlos Izpisúa Belmonte
Mar 15, 2006·Biochemical and Biophysical Research Communications·Kazuya OgawaHitoshi Niwa
Mar 30, 2006·Nature Cell Biology·Véronique AzuaraAmanda G Fisher
Apr 29, 2006·Nature Clinical Practice. Cardiovascular Medicine·Michael Poon
Jul 11, 2006·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Akiko TsumuraMasaki Okano
Aug 16, 2006·Molecular and Cellular Biology·Takashi HamazakiNaohiro Terada

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Citations

May 7, 2011·International Journal of Biological Sciences·Ana V Sánchez-SánchezJosé L Mullor
Dec 15, 2015·The International Journal of Biochemistry & Cell Biology·Bipasha Bose, P Sudheer Shenoy
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Sarah W ChanEvelyn K F Yim
Jul 23, 2011·Physiological Research·G NikčevićM Stevanović

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