Understanding sleep-wake mechanisms and drug discovery

Expert Opinion on Drug Discovery
Ana Clementina Equihua-BenítezRené Drucker-Colín

Abstract

Although not discernible at first glance, sleep is a highly active and regulated brain state. Although we spend practically one third of our lifetimes in this stage, its importance is often taken for granted. Sleep loss can lead to disease, error and economic loss. Our understanding of how sleep is achieved has greatly advanced in recent years, and with that, the management of sleep disorders has improved. There is still room for improvement and recently many new compounds have reached clinical trials with a few being approved for commercial use. Areas covered: In this review, the authors make the case of sleep disorders as a matter of public health. The mechanisms of sleep transition are discussed emphasizing the wake and sleep promoting interaction of different brain regions. Finally, advances in pharmacotherapy are examined in the context of chronic insomnia and narcolepsy. Expert opinion: The orexinergic system is an example of a breakthrough in sleep medicine that has catalyzed drug development. Nevertheless, sleep is a topic still with many unanswered questions. That being said, the melanin-concentrating hormone system is becoming increasingly relevant and we speculate it will be the next target of sleep medication.

References

Sep 1, 1978·The Journal of Clinical Endocrinology and Metabolism·G M VaughanJ W Sackman
Apr 1, 1967·Perceptual and Motor Skills·A KalesT E Wilson
Nov 1, 1994·Neurology·C HublinT Salmi
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·L de LeceaJ G Sutcliffe
May 9, 2000·Nature·T GallopinM Serafin
Oct 31, 2000·Neuron·T C ThannickalJ M Siegel
Nov 24, 2001·Trends in Neurosciences·C B SaperT E Scammell
Feb 9, 2002·Sleep·Michele L OkunEmmanuel Mignot
Sep 3, 2002·The Journal of Physiology·Natalia SuntsovaDennis McGinty
Jan 18, 2003·Sleep Medicine Reviews·Maurice M Ohayon
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Fang WangQian Zhao
Mar 8, 2003·Journal of Neuroendocrinology·C CajochenA Wirz-Justice
Apr 18, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Barbara E Jones
Nov 1, 1957·Electroencephalography and Clinical Neurophysiology·W DEMENT, N KLEITMAN
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michihiro MiedaMasashi Yanagisawa
Oct 29, 2004·The New England Journal of Medicine·Christopher P LandriganCharles A Czeisler
Mar 5, 2005·The Journal of Neuropsychiatry and Clinical Neurosciences·Lois E KrahnMichael H Silber
Jul 15, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maan Gee LeeBarbara E Jones
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Zhi-Li HuangOsamu Hayaishi
Mar 24, 2006·Sleep·David R HillmanLynne Pezzullo
May 12, 2006·Nature·Jun LuClifford B Saper
Dec 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David A ProberAlexander F Schier
Jul 31, 2007·Brain Research Reviews·Alfonso Fairén
Dec 8, 2007·European Journal of Pharmacology·Abdellah AhnaouFrank M Dautzenberg
Jan 30, 2008·Results and Problems in Cell Differentiation·Yumiko Saito, Hiroshi Nagasaki
Feb 26, 2008·Pharmacology, Biochemistry, and Behavior·Stephanie C Licata, James K Rowlett
Nov 1, 1949·Electroencephalography and Clinical Neurophysiology·G Moruzzi, H W Magoun
Sep 12, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan RaoXiao-Bing Gao
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Oum Kaltoum HassaniBarbara E Jones
Apr 29, 2009·Peptides·Douglas J MacNeil, Maria A Bednarek
Jun 2, 2009·Sleep Medicine Reviews·Dieter RiemannChristoph Nissen
Nov 27, 2009·Sleep Medicine Reviews·Luc Staner
Jul 28, 2010·CNS Drugs·Juliane WeberPaul L McCormack

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Citations

Nov 23, 2019·British Journal of Clinical Pharmacology·Daniel HoyerLaura H Jacobson
Jul 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Guilin RenMing Yang
Nov 27, 2020·Nature and Science of Sleep·Jian-Xiong AnWen-Hao Zhang

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