PMID: 16640116Apr 28, 2006Paper

Understanding structural brain changes in schizophrenia.

Dialogues in Clinical Neuroscience
Lynn E DeLisiKyle Brown

Abstract

Schizophrenia is a chronic progressive disorder that has at its origin structural brain changes in both white and gray matter. It is likely that these changes begin prior to the onset of clinical symptoms in cortical regions, particularly those concerned with language processing. Later, they can be detected by progressive ventricular enlargement. Current magnetic resonance imaging (MRI) technology can provide a valuable tool for detecting early changes in cortical atrophy and anomalous language processing, which may be predictive of who will develop schizophrenia.

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