Understanding taurine CNS activity using alternative zebrafish models

Neuroscience and Biobehavioral Reviews
Nathana J MezzomoDenis B Rosemberg

Abstract

Taurine is a highly abundant "amino acid" in the brain. Although the potential neuroactive role of taurine in vertebrates has long been recognized, the underlying molecular mechanisms related to its pleiotropic effects in the brain remain poorly understood. Due to the genetic tractability, rich behavioral repertoire, neurochemical conservation, and small size, the zebrafish (Danio rerio) has emerged as a powerful candidate for neuropsychopharmacology investigation and in vivo drug screening. Here, we summarize the main physiological roles of taurine in mammals, including neuromodulation, osmoregulation, membrane stabilization, and antioxidant action. In this context, we also highlight how zebrafish models of brain disorders may present interesting approaches to assess molecular mechanisms underlying positive effects of taurine in the brain. Finally, we outline recent advances in zebrafish drug screening that significantly improve neuropsychiatric translational research and small molecule screens.

Citations

Apr 9, 2020·International Journal of Molecular Sciences·Yam Nath PaudelMohd Farooq Shaikh
Jul 12, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Francini FranscesconDenis B Rosemberg
Jul 16, 2021·European Journal of Pharmacology·Kanandra Taisa Bertoncello, Carla Denise Bonan
Mar 19, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kanandra T BertoncelloDenis B Rosemberg
Feb 12, 2019·Hormones and Behavior·Nathana J MezzomoLeonardo J G Barcellos
May 22, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tâmie DuarteDenis B Rosemberg
Feb 28, 2020·Neurochemistry International·Francini FranscesconDenis B Rosemberg
Nov 5, 2020·Pharmacology, Biochemistry, and Behavior·Nathana J MezzomoLeonardo J G Barcellos

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