Dec 24, 2018

Understanding the Biology and Pathogenesis of the Kidney by Single-Cell Transcriptomic Analysis

Kidney Diseases
Yuting YeShaolin Shi

Abstract

Single-cell RNA-seq (scRNA-seq) has recently emerged as a revolutionary and powerful tool for biomedical research. However, there have been relatively few studies using scRNA-seq in the field of kidney study. scRNA-seq achieves gene expression profiling at single-cell resolution in contrast with the conventional methods of gene expression profiling, which are based on cell population and give averaged values of gene expression of the cells. Single-cell transcriptomic analysis is crucial because individual cells of the same type are highly heterogeneous in gene expression, which reflects the existence of subpopulations, different cellular states, or molecular dynamics, of the cells, and should be resolved for further insights. In addition, gene expression analysis of tissues or organs that usually comprise multiple cell types or subtypes results in data that are not fully applicable to any given cell type. scRNA-seq is capable of identifying all cell types and subtypes in a tissue, including those that are new or present in small quantity. With these unique capabilities, scRNA-seq has been used to dissect molecular processes in cell differentiation and to trace cell lineages in development. It is also used to analyze the cells i...Continue Reading

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Mentioned in this Paper

Single-Cell Analysis
Study
Research
Pathogenesis
Molecular_function
Sequence Determinations
Laboratory
Kidney
Organ
Gene Expression

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