Understanding the burden of idiopathic generalized epilepsy in the United States, Europe, and Brazil: An analysis from the National Health and Wellness Survey

Epilepsy & Behavior : E&B
Shaloo GuptaPhillipe Ryvlin

Abstract

The aim of this study was to understand the current burden of primary generalized tonic-clonic seizures (PGTCS) associated with idiopathic generalized epilepsy (IGE) as a function of seizure frequency. We analyzed data for (IGE) as a proxy measure of PGTCS. Little is known about the quality of life (QoL), health utility, productivity, healthcare resource utilization (HRU), and cost burden of PGTCS or IGE. Patients were identified from the US (2011, 2012, & 2013), 5EU (2011 & 2013), and Brazil (2011 & 2012) National Health and Wellness Survey, a nationally representative, internet-based survey of adults (18+ years). Patients that self-reported a diagnosis of IGE were categorized into seizure frequencies of: ≥1 seizure per week, 1-3 seizures per month, 1-4 seizures per year, or <1 seizure per year. QoL was measured using the SF-36v2 Mental (MCS) and Physical Component Summary (PCS) scores, health utilities with the SF-6D, productivity with the Work Productivity and Activity Impairment (WPAI) questionnaire, and HRU as reported in the past six months. Unit costs were estimated from the literature and multiplied against HRU values to calculate direct costs and WPAI values to calculate indirect costs. Generalized linear regression wa...Continue Reading

References

Apr 10, 2002·Journal of Health Economics·John BrazierMark Deverill
Apr 24, 2002·Neurology·Frank Gilliam
Mar 1, 2003·Epilepsy & Behavior : E&B·Frank Gilliam, Andres M. Kanner
Aug 23, 2005·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Stephen J Walters, John E Brazier
Jan 31, 2007·Neurology·D HirtzR Zalutsky
Jul 25, 2007·Neurology·Adam I Kaplin, Montel Williams
Apr 1, 1997·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·M J Eadie
Nov 2, 2011·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Kristian BolinKristina Källén
Mar 3, 2012·Epilepsy & Behavior : E&B·Adam StrzelczykHajo M Hamer
Jul 4, 2012·Epilepsy Research·Guillermina Garcia-MartinMarc Stefan Dawid-Milner
Nov 6, 2012·Epilepsy & Behavior : E&B·Andrew N WilnerAndrew Krueger
May 10, 2013·Epilepsia·Martin J Brodie
Jul 9, 2013·Epilepsy & Behavior : E&B·Rani A SarkisBarbara Dworetzky
Nov 10, 2013·PLoS Neglected Tropical Diseases·Elisa BrunoUNKNOWN COHEMI Project Study Group
Nov 19, 2013·Epilepsy & Behavior : E&B·Joyce A CramerMichael S Broder
Feb 25, 2014·Seizure : the Journal of the British Epilepsy Association·M de ZélicourtF Fagnani
Jul 6, 2014·Neurology·Laura J BonnettAnthony G Marson
Jul 11, 2014·Seizure : the Journal of the British Epilepsy Association·Se-Jin LeeSung-Pa Park
Aug 6, 2014·Epilepsia·Giorgia GiussaniUNKNOWN EPIRES Group
Sep 16, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Amir GorenMarco daCosta DiBonaventura

❮ Previous
Next ❯

Citations

Jun 23, 2016·Epilepsy Currents·Alica M GoldmanUNKNOWN American Epilepsy Society (AES)/National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Benchmark Stewards
Apr 7, 2018·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Jill DavisMark Small
Feb 6, 2020·Applied Health Economics and Health Policy·Thanpisit OunsirithupsakulNathorn Chaiyakunapruk
Aug 3, 2019·Cold Spring Harbor Molecular Case Studies·Drew M Thodeson, Jason Y Park
Sep 4, 2020·Epilepsy & Behavior : E&B·David King-StephensMei Lu
Feb 15, 2021·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Joanna JędrzejczakBrian Godman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.