Understanding the CD8 T-cell response in natural HIV control

F1000Research
Sushma Boppana, Paul Goepfert

Abstract

HIV-infected individuals who maintain control of virus without antiretroviral therapy (ART) are called HIV controllers. The immune responses of these individuals suppress HIV viral replication to low levels or, in the case of elite controllers, to undetectable levels. Although some research indicates a role for inferior virulence of the infecting viral strain in natural control, perhaps by way of defective Nef protein function, we find that the majority of research in HIV controllers highlights CD8 T cells as the main suppressor of viral replication. The most convincing evidence for this argument lies in the strong correlation between certain HLA-I alleles, especially B*57, and HIV control status, a finding that has been replicated by many groups. However, natural control can also occur in individuals lacking these specific HLA alleles, and our understanding of what constitutes an effective CD8 T-cell response remains an incomplete picture. Recent research has broadened our understanding of natural HIV control by illustrating the interactions between different immune cells, including innate immune effectors and antigen-presenting cells. For many years, the immune responses of the natural HIV controllers have been studied for cl...Continue Reading

References

Jan 26, 1995·The New England Journal of Medicine·F KirchhoffR C Desrosiers
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·S A MiguelesM Connors
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emma L TurnbullPersephone Borrow
Jan 26, 2007·Journal of Virology·Thomas C FriedrichDavid I Watkins
Jun 1, 2007·Journal of Virology·John T LoffredoDavid I Watkins
May 7, 2010·Journal of Virology·Karen A O'ConnellJoel N Blankson
May 28, 2010·Journal of Virology·Toshiyuki MiuraBruce D Walker
Jul 17, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Alejandra Peris-PertusaJosé M Benito
Nov 6, 2010·Science·UNKNOWN International HIV Controllers StudyMeng Zhao
Dec 3, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Zabrina L BrummeMark A Brockman
May 20, 2011·Journal of Virology·Philip A MuddDavid I Watkins
Mar 6, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philip A MuddDavid I Watkins
Jul 20, 2012·Journal of Virology·Catherine A BrennanBeth D Jamieson
Jan 8, 2013·Retrovirology·Philip MwimanziTakamasa Ueno
May 25, 2013·Science·Scott G HansenLouis J Picker
Nov 5, 2013·The Journal of Infectious Diseases·Sonya KrishnanIrini Sereti
Jun 27, 2014·Journal of Virology·Xiaomei T KuangMark A Brockman
Dec 17, 2014·The Journal of Infectious Diseases·Trevor A CrowellUNKNOWN HIV Research Network
Mar 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Beatriz Dominguez-MolinaEzequiel Ruiz-Mateos
Apr 26, 2016·The Journal of Clinical Investigation·Daniela BenatiLisa A Chakrabarti
May 18, 2016·Nature Medicine·Jonathan M CarlsonPaul A Goepfert
Jul 9, 2016·Clinical Science·Morgane GriesbeckMarcus Altfeld

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Citations

Jun 12, 2021·Communications Biology·Min Wen KuLaleh Majlessi
Jul 22, 2020·The American Journal of the Medical Sciences·Juan C Sarria, Ana M Vidal

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