Understanding the Complexity of Epigenetic Target Space

Journal of Medicinal Chemistry
Vineet Pande

Abstract

The purpose of this review is to provide an overview of the complexity of the epigenetic target space. Chemical modifications of histones and nucleic acids constitute a key epigenetic mechanism. Whereas modifications such as methylation and acetylation are well-known, there are many additional, less explored modifications described here. The writers, readers and erasers of such diverse modifications, which constitute a major portion of the potential epigenetic target space, are discussed, in addition to the various other protein families that do not fall under these three categories. Finally, disease relevance and druggability of epigenetic targets are discussed with concluding remarks about the richness and diversity they will provide for future targeted therapies.

References

May 1, 1978·Cell·L Sealy, R Chalkley
Jun 19, 1981·Science·M Ehrlich, R Y Wang
Jan 19, 2000·Nature·B D Strahl, C D Allis
Jun 8, 2001·Annual Review of Biochemistry·S Y RothC D Allis
Jan 13, 2006·Trends in Biochemical Sciences·Robert J Klose, Adrian P Bird
Mar 31, 2006·Current Topics in Microbiology and Immunology·A Jeltsch
Feb 3, 2007·Molecular & Cellular Proteomics : MCP·Yue ChenYingming Zhao
Feb 27, 2007·Cell·Bradley E BernsteinEric S Lander
Feb 27, 2007·Cell·Tony Kouzarides
Mar 17, 2007·Annual Review of Biochemistry·Mona D Shahbazian, Michael Grunstein
Sep 26, 2007·Annals of the New York Academy of Sciences·Akari SuzukiKazuhiko Yamamoto
Oct 20, 2007·Nucleic Acids Research·Dorota Piekna-PrzybylskaMaurille J Fournier
Sep 23, 2008·The International Journal of Biochemistry & Cell Biology·Stephanie SpangeOliver H Krämer
Oct 9, 2008·The Journal of Biological Chemistry·Ji-Joon Song, Robert E Kingston
Feb 24, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Julia M SchulzeMichael S Kobor
Sep 2, 2009·Nature Reviews. Drug Discovery·Robert A CopelandVictoria M Richon
Jan 23, 2010·The EMBO Journal·Jessica S WilliamsPaul Russell
Oct 15, 2010·Nature Biotechnology·Anna Portela, Manel Esteller
Jan 21, 2011·Nature·Raphaël Margueron, Danny Reinberg
Jan 21, 2011·International Journal of Molecular Medicine·Jian-Jun XieEn-Min Li
Feb 16, 2011·Cell Research·Andrew J Bannister, Tony Kouzarides
Mar 8, 2011·Journal of Cell Science·Takashi Nakagawa, Leonard Guarente
Mar 10, 2011·Nature Medicine·Manuel Rodríguez-Paredes, Manel Esteller
Apr 7, 2011·Protein & Cell·Chao Xu, Jinrong Min
May 20, 2011·Nature·Nathalie Véron, Antoine H F M Peters
Jun 10, 2011·Nature Reviews. Cancer·Boris G Wilson, Charles W M Roberts
Jul 2, 2011·Nature Reviews. Drug Discovery·Samia Burridge
Sep 29, 2011·Nucleic Acids Research·Anna GaultonJohn P Overington
Dec 8, 2011·Journal of Computer-aided Molecular Design·C SantiagoM Schapira
Dec 24, 2011·Acta Biochimica Et Biophysica Sinica·Jiang I Wu
Jan 31, 2012·Chemistry & Biology·Sachin Surade, Tom L Blundell
Feb 24, 2012·Molecular Biology of the Cell·Ewa NiedzialkowskaP Todd Stukenberg
Mar 6, 2012·Molecular & Cellular Proteomics : MCP·Zhongyu XieYingming Zhao
Apr 5, 2012·Nature Reviews. Genetics·Eric L Greer, Yang Shi
Apr 14, 2012·Nature Reviews. Drug Discovery·Cheryl H ArrowsmithMatthieu Schapira
May 2, 2012·Molecular and Cellular Biology·Ricardo Martinez-Zamudio, Hyo Chol Ha
May 12, 2012·Journal of Molecular Biology·Aleksandra A WatsonErnest D Laue
May 17, 2012·Cancer Discovery·Relja Popovic, Jonathan D Licht
Jun 22, 2012·Bioinformatics·Lihua LiuMatthieu Schapira
Jul 14, 2012·Journal of Medicinal Chemistry·Lewis R VidlerSwen Hoelder
Aug 17, 2012·The New England Journal of Medicine·Mark A DawsonBrian J P Huntly
Sep 6, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Dorine RossettoJacques Côté

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Citations

Oct 21, 2016·Drug Development Research·Walter H MoosKosta Steliou
Oct 3, 2017·Briefings in Functional Genomics·Luciane T KagoharaElana J Fertig
Nov 7, 2017·Nutrients·Guilherme Felipe Santos FernandesJean Leandro Dos Santos
Jul 4, 2018·Angewandte Chemie·Daniel MoserJosep Cornella
Aug 7, 2019·Journal of Biomolecular Structure & Dynamics·Leandro A Alves AvelarKatarina Nikolic
Nov 9, 2019·Future Medicinal Chemistry·Saurabh Loharch, Raman Parkesh
Apr 11, 2017·International Journal of Molecular Medicine·Meng-Hsuan ChengHui-Fen Chiu
Dec 21, 2016·Journal of Computer-aided Molecular Design·Herman van VlijmenTara Mirzadegan
Nov 13, 2018·Frontiers in Oncology·Katia C GenadryCorinne M Linardic
Jun 2, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yuki SawaiKatsuhiro Uzawa
Jul 21, 2016·Clinical Epigenetics·David WeigtGuillaume Médard
May 28, 2021·Journal of Medicinal Chemistry·Adam I Green, George M Burslem

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