Understanding the Concept of Health Care-Associated Pneumonia in Lung Transplant Recipients

Chest
Federico PalacioM I Restrepo

Abstract

Limited data are available regarding the etiologic impact of health care-associated pneumonia (HCAP) in lung transplant recipients. Therefore, our aim was to evaluate the microbiologic differences between HCAP and hospital-acquired pneumonia (HAP)/ventilator-associated pneumonia (VAP) in lung transplant recipients with a radiographically confirmed diagnosis of pneumonia. We performed a retrospective cohort study of lung transplant recipients with pneumonia at one transplant center over a 7-year period. Eligible patients included lung transplant recipients who developed a first episode of radiographically confirmed pneumonia ≥ 48 h following transplantation. HCAP, HAP, and VAP were classified according to the American Thoracic Society/Infectious Diseases Society of America 2005 guidelines. χ² and Student t tests were used to compare categorical and continuous variables, respectively. Sixty-eight lung transplant recipients developed at least one episode of pneumonia. HCAP (n = 42; 62%) was most common, followed by HAP/VAP (n = 26; 38%) stratified in HAP (n = 20; 77%) and VAP (n = 6; 23%). Pseudomonas aeruginosa was the predominantly isolated organism (n = 22; 32%), whereas invasive aspergillosis was uncommon (< 10%). Multiple-dru...Continue Reading

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Citations

Dec 24, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J ShankarC J Clancy
Aug 26, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Sushma K Cribbs, James M Beck
Mar 7, 2019·Intensive Care Medicine·Tobias WelteJordi Rello
Feb 16, 2020·International Journal of Molecular Sciences·Manuela CarugatiIfalt Working Group
Nov 12, 2020·The Journal of Hospital Infection·J A SuayaT Verstraeten
May 25, 2021·Seminars in Respiratory and Critical Care Medicine·Alicia B Mitchell, Allan R Glanville

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