Understanding the coronary circulation through studies at the microvascular level

Circulation
M L MarcusK G Lamping

Abstract

Studies of the coronary circulation have divided vascular resistances into three large components: large vessels, small resistance vessels, and veins. Studies of the epicardial microcirculation in the beating heart using stroboscopic illumination have suggested that resistance is more precisely controlled in different segments of the circulation. Measurements of coronary pressure in different sized arteries and arterioles have indicated that under normal conditions, 45-50% of total coronary vascular resistance resides in vessels larger than 100 microns. This distribution of vascular resistance can be altered in a nonuniform manner by a variety of physiological (autoregulation, increases in myocardial oxygen consumption, sympathetic stimulation) and pharmacological stimuli (norepinephrine, papaverine, dipyridamole, serotonin, vasopressin, nitroglycerin, adenosine, and endothelin). Studies of exchange of macromolecules in the microcirculation using fluorescent-labeled dextrans have also identified the size of the small pore (35-50 A) in coronary microvessels that can be altered by myocardial ischemia. Studies of the coronary microcirculation have demonstrated that the control of vascular resistance is extremely complex, and mecha...Continue Reading

References

Nov 1, 1987·Progress in Cardiovascular Diseases·M A YoungS F Vatner
Feb 1, 1985·Journal of Applied Physiology·E M Renkin
Apr 1, 1974·Circulation Research·H TillmannsR J Bing
May 1, 1982·Canadian Journal of Physiology and Pharmacology·G A Klassen, J A Armour

❮ Previous
Next ❯

Citations

Oct 1, 1996·Catheterization and Cardiovascular Diagnosis·P H van der VoortN H Pijls
Sep 1, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E KahlerA Haase
Jan 8, 2000·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·C Seiler, B Meier
Jun 1, 1993·Catheterization and Cardiovascular Diagnosis·R F Wilson, D D Laxson
Aug 1, 1997·Clinical Cardiology·A LickermanK C Dellsperger
Sep 5, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Ornella E RimoldiPaolo G Camici
Apr 7, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·V SchächingerA M Zeiher
Apr 25, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Paul Knaapen, Mark Lubberink
May 27, 2009·Basic Research in Cardiology·Paul KnaapenAlbert C van Rossum
Jan 20, 2007·Cardiovascular Drugs and Therapy·Mario TogniOtto M Hess
Mar 19, 2008·Medical & Biological Engineering & Computing·Masami Goto, Seiichi Mochizuki
Sep 19, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Shreenidhi M VenurajuAvijit Lahiri
Mar 25, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Amalia PeixMaurizio Dondi
Jan 11, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Henry Gewirtz
Mar 1, 1996·International Journal of Cardiology·D HasdaiA Lerman
Sep 2, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Amit R PatelChristopher M Kramer
Oct 12, 2000·Nihon rinsho. Japanese journal of clinical medicine·Y SaitoR Nagai
Aug 5, 1998·Pharmacology & Therapeutics·E Thorin, S M Shreeve
Jan 5, 1999·International Journal of Cardiology·W L LeeC T Ting
Dec 12, 2001·Journal of the American College of Cardiology·M BillingerO M Hess
Feb 1, 1991·Journal of the American College of Cardiology·A MaseriT Crake
Feb 11, 1991·Journal of the American College of Cardiology·H G Kemp
Jul 1, 1997·Journal of the American College of Cardiology·J Koglin, W von Scheidt
Feb 14, 1998·Journal of the American College of Cardiology·J L HoughtonA A Carr
Nov 11, 1998·Journal of the American College of Cardiology·H MurakamiM Nishimura
Sep 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·J R Lindner, S Kaul
Nov 1, 1996·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·R F Wilson
Jun 27, 1996·The New England Journal of Medicine·R F Wilson
May 29, 1999·Journal of Computer Assisted Tomography·L O LermanE L Ritman
Oct 4, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Hannelore I G RingeGerhard Gaedicke
Dec 24, 2002·Annals of the New York Academy of Sciences·Stefan MöhlenkampErik L Ritman
Oct 1, 1992·Archives of Disease in Childhood·J AuJ H Dark
Mar 1, 1995·Archives of Disease in Childhood·J L Gibbs

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