Understanding the determinants of health-related quality of life in rheumatoid arthritis-associated interstitial lung disease

Respiratory Medicine
Jake G NataliniJoyce S Lee

Abstract

Health-related quality of life (HRQL) is impaired among patients with interstitial lung disease (ILD). Little is understood about HRQL in specific subtypes of ILD. The aim of this study was to characterize and identify clinical determinants of HRQL among patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and compare them to patients with idiopathic pulmonary fibrosis (IPF). We identified patients with a diagnosis of RA-ILD and IPF from an ongoing longitudinal cohort of ILD patients. HRQL was measured at their baseline visit using the Short Form Health Survey (SF-36), versions 1 and 2. Regression models were used to characterize and understand the relationship between selected baseline clinical covariates, the physical component score (PCS) and mental component score (MCS) of the SF-36. RA-ILD patients (n = 50) were more likely to be younger and female compared to IPF patients (n = 50). After controlling for age and pulmonary function, RA-ILD patients had a lower HRQL compared to IPF patients, as measured by the PCS (P = 0.03), with significant differences in two of four PCS domains - bodily pain (P < 0.01) and general health (P = 0.01). Clinical covariates most strongly associated with a lower PCS ...Continue Reading

Citations

Feb 23, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Amanda J PiperVasileios Kouranos
Mar 2, 2018·PharmacoEconomics·Alex DiamantopoulosToby M Maher
Jul 2, 2019·Current Opinion in Pulmonary Medicine·Julie Morisset, Joyce S Lee
Aug 1, 2019·Current Opinion in Pulmonary Medicine·Julie Morisset, Joyce S Lee
Aug 20, 2019·Clinical Rheumatology·Aryeh Fischer, Jörg Distler
Nov 13, 2020·Respiratory Research·Qinxue ShenHong Peng
Jul 21, 2021·American Journal of Respiratory and Critical Care Medicine·Kerri I AronsonJeffrey J Swigris
Aug 23, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Gustavo CiteraDario Ponce de Leon

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