Understanding the Effects of Nanocapsular Mechanical Property on Passive and Active Tumor Targeting

ACS Nano
Yue HuiChun-Xia Zhao

Abstract

The physicochemical properties of nanoparticles (size, charge, and surface chemistry, etc.) influence their biological functions often in complex and poorly understood ways. This complexity is compounded when the nanostructures involved have variable mechanical properties. Here, we report the synthesis of liquid-filled silica nanocapsules (SNCs, ∼ 150 nm) having a wide range of stiffness (with Young's moduli ranging from 704 kPa to 9.7 GPa). We demonstrate a complex trade-off between nanoparticle stiffness and the efficiencies of both immune evasion and passive/active tumor targeting. Soft SNCs showed 3 times less uptake by macrophages than stiff SNCs, while the uptake of PEGylated SNCs by cancer cells was independent of stiffness. In addition, the functionalization of stiff SNCs with folic acid significantly enhanced their receptor-mediated cellular uptake, whereas little improvement for the soft SNCs was conferred. Further in vivo experiments confirmed these findings and demonstrated the critical role of nanoparticle mechanical properties in regulating their interactions with biological systems.

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Citations

Aug 1, 2019·Angewandte Chemie·Guangze YangChun-Xia Zhao
Feb 27, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chenyang YaoAiguo Wu
Apr 30, 2020·Chembiochem : a European Journal of Chemical Biology·Guangze YangChun-Xia Zhao
Aug 31, 2020·ChemPlusChem·Yun LiuChun-Xia Zhao
Jun 14, 2020·Angewandte Chemie·Jingxin ShaoJan C M van Hest
Mar 28, 2020·Chemical Society Reviews·Zheng LiXiangliang Yang
May 20, 2020·Science Advances·Yue HuiChun-Xia Zhao
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Nov 1, 2020·International Journal of Molecular Sciences·Parinaz SabourianAshok Kakkar
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Mar 20, 2021·Drug Discovery Today·Zirong DongZhongjian Chen
Sep 1, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marzieh MohammadiMona Alibolandi
Jan 15, 2019·Advanced Drug Delivery Reviews·Zongmin ZhaoSamir Mitragotri
Apr 21, 2021·ACS Applied Materials & Interfaces·Peilin GuJianlei Shen
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Jun 15, 2021·Acta Biomaterialia·Da ZouChun-Xia Zhao
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May 21, 2020·Nano Letters·Zhong-Jian ChenChao Fang
Jul 10, 2019·ACS Nano·Yue HuiChun-Xia Zhao
Sep 29, 2020·Nano Letters·Nourin AlsharifKeith A Brown
Oct 1, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Xuebin MaJingcheng Hao
Oct 16, 2021·Proceedings of the National Academy of Sciences of the United States of America·Stephanie M KongPaula T Hammond
Oct 15, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chaewon ParkSeungjoo Haam
Oct 10, 2021·Advanced Healthcare Materials·Zhaoyu MaHeyou Han
Aug 11, 2020·Journal of Colloid and Interface Science· TengjisiChun-Xia Zhao

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