Understanding the evolving phenotype of vascular complications in telomere biology disorders

Angiogenesis
Cecilia HiggsClinical Care Consortium for Telomere-associated Ailments (CCCTAA)

Abstract

Vascular complications such as bleeding due to gastrointestinal telangiectatic anomalies, pulmonary arteriovenous malformations, hepatopulmonary syndrome, and retinal vessel abnormalities are being reported in patients with telomere biology disorders (TBDs) more frequently than previously described. The international clinical care consortium of telomere-associated ailments and family support group Dyskeratosis Congenita Outreach, Inc. held a workshop on vascular abnormalities in the TBDs at the National Cancer Institute in October 2017. Clinicians and basic scientists reviewed current data on vascular complications, hypotheses for the underlying biology and developed new collaborations to address the etiology and clinical management of vascular complications in TBDs.

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Citations

Jan 24, 2019·Blood·Alyssa L Kennedy, Akiko Shimamura
Sep 4, 2019·Expert Review of Hematology·Marena R Niewisch, Sharon A Savage
Oct 4, 2020·Pediatric Dermatology·Francisca MorgadoInês Coutinho
Oct 25, 2020·Orphanet Journal of Rare Diseases·Michael KarremannMatthias Dürken
Jun 12, 2020·Seminars in Liver Disease·Daniel D Penrice, Douglas A Simonetto
Dec 3, 2020·Frontiers in Cell and Developmental Biology·Jia Zheng, Chengzhi Lu
Oct 31, 2020·The Journal of Pediatrics·Thomas F Michniacki, Angela C Weyand
Sep 25, 2020·The Journal of Pediatrics·Ryan W HimesAlison A Bertuch
Apr 14, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lijuan ZhangHongyi Cai
Aug 19, 2021·Best Practice & Research. Clinical Haematology·Emma M GroarkeKatherine R Calvo
Sep 22, 2021·Stem Cells Translational Medicine·Moumita GhoshSusan D Reynolds

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Methods Mentioned

BETA
MDS
biopsy

Clinical Trials Mentioned

NCT01659606

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