Understanding the Generation of Network Bursts by Adaptive Oscillatory Neurons

Frontiers in Neuroscience
Tanguy FardetPascal Monceau

Abstract

Experimental and numerical studies have revealed that isolated populations of oscillatory neurons can spontaneously synchronize and generate periodic bursts involving the whole network. Such a behavior has notably been observed for cultured neurons in rodent's cortex or hippocampus. We show here that a sufficient condition for this network bursting is the presence of an excitatory population of oscillatory neurons which displays spike-driven adaptation. We provide an analytic model to analyze network bursts generated by coupled adaptive exponential integrate-and-fire neurons. We show that, for strong synaptic coupling, intrinsically tonic spiking neurons evolve to reach a synchronized intermittent bursting state. The presence of inhibitory neurons or plastic synapses can then modulate this dynamics in many ways but is not necessary for its appearance. Thanks to a simple self-consistent equation, our model gives an intuitive and semi-quantitative tool to understand the bursting behavior. Furthermore, it suggests that after-hyperpolarization currents are sufficient to explain bursting termination. Through a thorough mapping between the theoretical parameters and ion-channel properties, we discuss the biological mechanisms that co...Continue Reading

References

Mar 1, 1990·Trends in Neurosciences·B W Connors, M J Gutnick
Jan 1, 1993·Biological cybernetics·D Somers, N Kopell
Aug 11, 1998·Neuron·A Lüthi, D A McCormick
May 22, 2001·Neural Computation·C van Vreeswijk, D Hansel
May 17, 2002·Progress in Neurobiology·Pankaj Sah, E S Louise Faber
Dec 23, 2003·The European Journal of Neuroscience·Fivos VogalisBarrie Lancaster
Dec 8, 2004·Current Opinion in Neurobiology·Jan-Marino RamirezFernando Peña
Jul 15, 2005·Journal of Neurophysiology·Romain Brette, Wulfram Gerstner
Jun 29, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Daniel A WagenaarSteve M Potter
Apr 9, 2008·IEEE Transactions on Bio-medical Engineering·Jan StegengaWim L C Rutten
Nov 18, 2008·Biological cybernetics·Jonathan Touboul, Romain Brette
Nov 18, 2008·Biological cybernetics·Richard NaudWulfram Gerstner
Feb 5, 2009·Drug Discovery Today. Disease Models·Maxim BazhenovTerrence J Sejnowski
Dec 3, 2009·Nature Reviews. Neuroscience·Aaron G Blankenship, Marla B Feller
Aug 13, 2011·Journal of Neurophysiology·Dror Cohen, Menahem Segal
Nov 1, 2012·Frontiers in Cellular Neuroscience·Rodrigo AndradeAnastasios V Tzingounis
Mar 2, 2013·Frontiers in Computational Neuroscience·Moritz AugustinKlaus Obermayer
Apr 22, 2014·Progress in Brain Research·Ilya A RybakJeffrey C Smith
Mar 11, 2016·Proceedings of the National Academy of Sciences of the United States of America·Yaron PennElisha Moses
Mar 18, 2016·Journal of Neurophysiology·Jyothsna SureshWim van Drongelen
Apr 4, 2017·Neural Networks : the Official Journal of the International Neural Network Society·F S BorgesA M Batista

❮ Previous
Next ❯

Citations

Oct 6, 2020·Frontiers in Physiology·Paulo R ProtacheviczJürgen Kurths
Dec 18, 2020·Frontiers in Systems Neuroscience·Paulo R ProtacheviczJurgen Kurths
Aug 27, 2021·The Journal of Physical Chemistry. B·Agustín Bou, Juan Bisquert

❮ Previous
Next ❯

Software Mentioned

scipy
learn
NNGT
igraph
scikit
NEST

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Related Papers

Journal of Computational Neuroscience
P F Rowat, Robert C Elson
Frontiers in Computational Neuroscience
Ho Ka ChanThomas Nowotny
© 2022 Meta ULC. All rights reserved