Understanding the genetic liability to schizophrenia through the neuroepigenome

Schizophrenia Research
John F FullardPanos Roussos

Abstract

The Psychiatric Genomics Consortium-Schizophrenia Workgroup (PGC-SCZ) recently identified 108 loci associated with increased risk for schizophrenia (SCZ). The vast majority of these variants reside within non-coding sequences of the genome and are predicted to exert their effects by affecting the mechanism of action of cis regulatory elements (CREs), such as promoters and enhancers. Although a number of large-scale collaborative efforts (e.g. ENCODE) have achieved a comprehensive mapping of CREs in human cell lines or tissue homogenates, it is becoming increasingly evident that many risk-associated variants are enriched for expression Quantitative Trait Loci (eQTLs) and CREs in specific tissues or cells. As such, data derived from previous research endeavors may not capture fully cell-type and/or region specific changes associated with brain diseases. Coupling recent technological advances in genomics with cell-type specific methodologies, we are presented with an unprecedented opportunity to better understand the genetics of normal brain development and function and, in turn, the molecular basis of neuropsychiatric disorders. In this review, we will outline ongoing efforts towards this goal and will discuss approaches with the...Continue Reading

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Citations

Apr 8, 2017·International Journal of Molecular Sciences·Ariel Cariaga-Martinez, Raúl Alelú-Paz
May 10, 2018·Molecular Psychiatry·Mads E HaubergUNKNOWN CommonMind Consortium
Jun 30, 2018·Molecular Psychiatry·Gabor EgervariYasmin L Hurd
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May 5, 2018·International Journal of Molecular Sciences·Ariel Ernesto Cariaga-MartínezRaúl Alelú-Paz
Jul 7, 2019·Schizophrenia Research·Prashanth RajarajanKristen J Brennand

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